Sarcomas With Spindle Cell Morphology

Paolo Collini, Poul H. B. Sorensen, Shreyaskumar Patel, Jean-Yves Blay, Rolf D. Issels, Robert G. Maki, Mikael Eriksson, Xavier Garcia del Muro

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceedingpeer-review

19 Citations (SciVal)


In the days before the term “high-grade undifferentiated pleomorphic sarcoma” came into use, one of the most common sarcoma diagnoses was “malignant fibrous histiocytoma,” and before that, in an era before immunohistochemistry, “fibrosarcoma” was used to describe most sarcomas. “Spindle cell” is a descriptive phrase that denotes the cellular shape of many of the sarcomas encountered in the adult population. As a result, they are usually treated differently from small round cell sarcomas, and have different biological characteristics than those tumors and sarcomas with epithelioid morphology. As a very broad generalization, sarcomas with a spindle cell microscopic morphology occur in adults and are treated primarily with surgery and often adjuvant or neoadjuvant radiation as primary therapy. In comparison to small round cell sarcomas such as Ewing sarcoma, the use of adjuvant chemotherapy remains controversial, and the sensitivity of these tumors to chemotherapy in the metastatic setting is highly variable. In this article, we describe some of the clinical and biological characteristics of this group of sarcomas.
Original languageEnglish
Title of host publicationSeminars in Oncology
PublisherW.B. Saunders
Publication statusPublished - 2009
EventInternational Symposium on Sarcomas and Gastrointestinal Stromal Tumors - Milan, Italy
Duration: 2008 May 132008 May 14

Publication series

ISSN (Print)0093-7754


ConferenceInternational Symposium on Sarcomas and Gastrointestinal Stromal Tumors

Subject classification (UKÄ)

  • Cancer and Oncology


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