Secondhand Smoke Exposure Causes Bronchial Hyperreactivity via Transcriptionally Upregulated Endothelin and 5-hydroxytryptamine 2A Receptors.

Lei Cao; Yaping Zhang; Yong-Xiao Cao; Lars Edvinsson; Cang-Bao Xu

doi:10.1371/journal.pone.0044170

Secondhand Smoke Exposure Causes Bronchial Hyperreactivity via Transcriptionally Upregulated Endothelin and 5-hydroxytryptamine 2A Receptors.

Lei Cao, Yaping Zhang, Yong-Xiao Cao, Lars Edvinsson, Cang-Bao Xu

Medicine, Lund

Research output: Contribution to journal › Article › peer-review

18 Citations (SciVal)

139 Downloads (Pure)

Abstract

Cigarette smoke exposure is strongly associated with airway hyperreactivity (AHR) which is the main characteristic seen in asthma. The intracellular MAPK signaling pathways are suggested to be associated with the airway damage to the AHR. In the present study, we hypothesize that secondhand cigarette smoke (SHS) exposure upregulates the bronchial contractile receptors via activation of the Raf/ERK/MAPK pathway.

Original language	English
Article number	e44170
Journal	PLoS ONE
Volume	7
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0044170
Publication status	Published - 2012

Subject classification (UKÄ)

Other Clinical Medicine

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10.1371/journal.pone.0044170

Plos_Cao_et_al

http://www.ncbi.nlm.nih.gov/pubmed/22952915?dopt=Abstract

18 Citations
1 Doctoral Thesis (compilation)

Receptor Upregulation and MAPK Activity in Arteries and Bronchi Following Secondhand Smoke Exposure
Cao, L., 2013, Faculty of Medicine, Lund University. 127 p.
Research output: Thesis › Doctoral Thesis (compilation)

Cite this

@article{733304beb79546828916cd1774ecdcab,

title = "Secondhand Smoke Exposure Causes Bronchial Hyperreactivity via Transcriptionally Upregulated Endothelin and 5-hydroxytryptamine 2A Receptors.",

abstract = "Cigarette smoke exposure is strongly associated with airway hyperreactivity (AHR) which is the main characteristic seen in asthma. The intracellular MAPK signaling pathways are suggested to be associated with the airway damage to the AHR. In the present study, we hypothesize that secondhand cigarette smoke (SHS) exposure upregulates the bronchial contractile receptors via activation of the Raf/ERK/MAPK pathway.",

author = "Lei Cao and Yaping Zhang and Yong-Xiao Cao and Lars Edvinsson and Cang-Bao Xu",

year = "2012",

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language = "English",

volume = "7",

journal = "PLoS ONE",

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AU - Cao, Lei

AU - Zhang, Yaping

AU - Cao, Yong-Xiao

AU - Edvinsson, Lars

AU - Xu, Cang-Bao

PY - 2012

Y1 - 2012

N2 - Cigarette smoke exposure is strongly associated with airway hyperreactivity (AHR) which is the main characteristic seen in asthma. The intracellular MAPK signaling pathways are suggested to be associated with the airway damage to the AHR. In the present study, we hypothesize that secondhand cigarette smoke (SHS) exposure upregulates the bronchial contractile receptors via activation of the Raf/ERK/MAPK pathway.

AB - Cigarette smoke exposure is strongly associated with airway hyperreactivity (AHR) which is the main characteristic seen in asthma. The intracellular MAPK signaling pathways are suggested to be associated with the airway damage to the AHR. In the present study, we hypothesize that secondhand cigarette smoke (SHS) exposure upregulates the bronchial contractile receptors via activation of the Raf/ERK/MAPK pathway.

U2 - 10.1371/journal.pone.0044170

DO - 10.1371/journal.pone.0044170

M3 - Article

C2 - 22952915

VL - 7

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 8

M1 - e44170

ER -

Secondhand Smoke Exposure Causes Bronchial Hyperreactivity via Transcriptionally Upregulated Endothelin and 5-hydroxytryptamine 2A Receptors.

Abstract

Subject classification (UKÄ)

Access to Document

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Research output

Receptor Upregulation and MAPK Activity in Arteries and Bronchi Following Secondhand Smoke Exposure

Cite this