Secondhand Smoke Exposure Causes Bronchial Hyperreactivity via Transcriptionally Upregulated Endothelin and 5-hydroxytryptamine 2A Receptors.

Lei Cao, Yaping Zhang, Yong-Xiao Cao, Lars Edvinsson, Cang-Bao Xu

Research output: Contribution to journalArticlepeer-review

18 Citations (SciVal)
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Abstract

Cigarette smoke exposure is strongly associated with airway hyperreactivity (AHR) which is the main characteristic seen in asthma. The intracellular MAPK signaling pathways are suggested to be associated with the airway damage to the AHR. In the present study, we hypothesize that secondhand cigarette smoke (SHS) exposure upregulates the bronchial contractile receptors via activation of the Raf/ERK/MAPK pathway.
Original languageEnglish
Article numbere44170
JournalPLoS ONE
Volume7
Issue number8
DOIs
Publication statusPublished - 2012

Subject classification (UKÄ)

  • Other Clinical Medicine

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