Sensitivity of mongolian gerbils to trichloroethylene exposure during neonatal growth

Per Kjellstrand, Lennart Månsson, M Bjerkemo, Jan Lanke, Björn Holmquist, Lena Zetterqvist

Research output: Contribution to journalArticlepeer-review

Abstract

Continuous exposure of young mongolian gerbils to trichloroethylene (230 ppm) was started at different times during the first month of life. The onset of exposure was accompanied by an increased number of deaths among the pups and by an immediate reduction in growth rate. The proportion of dead pups was greatest when exposure was started at birth, and decreased rapidly with increasing age at onset of exposure. Growth rate was partially restored approx. 1 week after the onset of exposure. After weaning the effect of the exposure on growth decreased, and the variation in the effect among different litters was considerably reduced. The enhanced sensitivity of the pups to trichloroethylene (TCE) exposure is believed to be due to a disturbance in the mother-offspring relationship.
Original languageEnglish
Pages (from-to)97-101
JournalToxicology Letters
Volume14
Issue number1-2
DOIs
Publication statusPublished - 1982

Subject classification (UKÄ)

  • Probability Theory and Statistics

Keywords

  • Mongolian gerbil
  • trichloroethylene
  • Meriones unguiculatus
  • neonatal
  • growth

Fingerprint

Dive into the research topics of 'Sensitivity of mongolian gerbils to trichloroethylene exposure during neonatal growth'. Together they form a unique fingerprint.

Cite this