SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis

G Appendino; S Prosperini; Carola Valdivia; M Ballero; G Colombano; R A Billington; A A Genazzani; Olov Sterner

doi:10.1021/np050115m

SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis

G Appendino, S Prosperini, Carola Valdivia, M Ballero, G Colombano, R A Billington, A A Genazzani, Olov Sterner

Centre for Analysis and Synthesis

Research output: Contribution to journal › Article › peer-review

Abstract

An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.

Original language	English
Pages (from-to)	1213-1217
Journal	Journal of Natural Products
Volume	68
Issue number	8
DOIs	https://doi.org/10.1021/np050115m
Publication status	Published - 2005

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)

Subject classification (UKÄ)

Organic Chemistry

Access to Document

10.1021/np050115m

Cite this

@article{6ae107364a0d44fa926b2eac5489e690,

title = "SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis",

abstract = "An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.",

author = "G Appendino and S Prosperini and Carola Valdivia and M Ballero and G Colombano and Billington, {R A} and Genazzani, {A A} and Olov Sterner",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)",

year = "2005",

doi = "10.1021/np050115m",

language = "English",

volume = "68",

pages = "1213--1217",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "The American Chemical Society (ACS)",

number = "8",

}

TY - JOUR

T1 - SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis

AU - Appendino, G

AU - Prosperini, S

AU - Valdivia, Carola

AU - Ballero, M

AU - Colombano, G

AU - Billington, R A

AU - Genazzani, A A

AU - Sterner, Olov

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)

PY - 2005

Y1 - 2005

N2 - An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.

AB - An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.

U2 - 10.1021/np050115m

DO - 10.1021/np050115m

M3 - Article

SN - 0163-3864

VL - 68

SP - 1213

EP - 1217

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 8

ER -

SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis

Abstract

Bibliographical note

Subject classification (UKÄ)

Access to Document

Fingerprint

Cite this