Serological assessment for celiac disease in IgA deficient adults.

Ning Wang; Lennart Truedsson; Kerstin Elvin; Bengt A Andersson; Johan Rönnelid; Lucia Mincheva-Nilsson; Annica Lindkvist; Jonas F Ludvigsson; Lennart Hammarström; Charlotte Dahle

doi:10.1371/journal.pone.0093180

Serological assessment for celiac disease in IgA deficient adults.

Ning Wang, Lennart Truedsson, Kerstin Elvin, Bengt A Andersson, Johan Rönnelid, Lucia Mincheva-Nilsson, Annica Lindkvist, Jonas F Ludvigsson, Lennart Hammarström, Charlotte Dahle

Division of Microbiology, Immunology and Glycobiology - MIG

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Abstract

Selective immunoglobulin A deficiency is the most common primary immunodeficiency disorder that is strongly overrepresented among patients with celiac disease (CD). IgG antibodies against tissue transglutaminase (tTG) and deamidated gliadin peptides (DGP) serve as serological markers for CD in IgA deficient individuals, although the diagnostic value remains uncertain. The aim of this study was to investigate the prevalence of these markers in a large cohort of IgA deficient adults with confirmed or suspected CD and relate the findings to gluten free diet.

Original language	English
Article number	e93180
Journal	PLoS ONE
Volume	9
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0093180
Publication status	Published - 2014

Subject classification (UKÄ)

Microbiology in the medical area
Immunology in the medical area

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PLoS__Wang_et_al

http://www.ncbi.nlm.nih.gov/pubmed/24709954?dopt=Abstract

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title = "Serological assessment for celiac disease in IgA deficient adults.",

abstract = "Selective immunoglobulin A deficiency is the most common primary immunodeficiency disorder that is strongly overrepresented among patients with celiac disease (CD). IgG antibodies against tissue transglutaminase (tTG) and deamidated gliadin peptides (DGP) serve as serological markers for CD in IgA deficient individuals, although the diagnostic value remains uncertain. The aim of this study was to investigate the prevalence of these markers in a large cohort of IgA deficient adults with confirmed or suspected CD and relate the findings to gluten free diet.",

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AU - Wang, Ning

AU - Truedsson, Lennart

AU - Elvin, Kerstin

AU - Andersson, Bengt A

AU - Rönnelid, Johan

AU - Mincheva-Nilsson, Lucia

AU - Lindkvist, Annica

AU - Ludvigsson, Jonas F

AU - Hammarström, Lennart

AU - Dahle, Charlotte

PY - 2014

Y1 - 2014

N2 - Selective immunoglobulin A deficiency is the most common primary immunodeficiency disorder that is strongly overrepresented among patients with celiac disease (CD). IgG antibodies against tissue transglutaminase (tTG) and deamidated gliadin peptides (DGP) serve as serological markers for CD in IgA deficient individuals, although the diagnostic value remains uncertain. The aim of this study was to investigate the prevalence of these markers in a large cohort of IgA deficient adults with confirmed or suspected CD and relate the findings to gluten free diet.

AB - Selective immunoglobulin A deficiency is the most common primary immunodeficiency disorder that is strongly overrepresented among patients with celiac disease (CD). IgG antibodies against tissue transglutaminase (tTG) and deamidated gliadin peptides (DGP) serve as serological markers for CD in IgA deficient individuals, although the diagnostic value remains uncertain. The aim of this study was to investigate the prevalence of these markers in a large cohort of IgA deficient adults with confirmed or suspected CD and relate the findings to gluten free diet.

U2 - 10.1371/journal.pone.0093180

DO - 10.1371/journal.pone.0093180

M3 - Article

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SN - 1932-6203

VL - 9

JO - PLoS ONE

JF - PLoS ONE

IS - 4

M1 - e93180

ER -

Serological assessment for celiac disease in IgA deficient adults.

Abstract

Subject classification (UKÄ)

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