TY - JOUR
T1 - Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.
AU - Bennet, Hedvig
AU - Mollet, Ines
AU - Balhuizen, Alexander
AU - Medina Benavente, Anya
AU - Nagorny, Cecilia
AU - Bagge, Annika
AU - Fadista, Joao
AU - Ottosson Laakso, Emilia
AU - Vikman, Petter
AU - Dekker Nitert, Marloes
AU - Eliasson, Lena
AU - Wierup, Nils
AU - Artner, Isabella
AU - Fex, Malin
PY - 2016
Y1 - 2016
N2 - The Gq-coupled 5-hydroxytryptamine 2B (5-HT2B) receptor is known to regulate the proliferation of islet beta cells during pregnancy. However, the role of serotonin in the control of insulin release is still controversial. The aim of the present study was to explore the role of the 5-HT2B receptor in the regulation of insulin secretion in mouse and human islets, as well as in clonal INS-1(832/13) cells.
AB - The Gq-coupled 5-hydroxytryptamine 2B (5-HT2B) receptor is known to regulate the proliferation of islet beta cells during pregnancy. However, the role of serotonin in the control of insulin release is still controversial. The aim of the present study was to explore the role of the 5-HT2B receptor in the regulation of insulin secretion in mouse and human islets, as well as in clonal INS-1(832/13) cells.
U2 - 10.1007/s00125-015-3847-6
DO - 10.1007/s00125-015-3847-6
M3 - Article
C2 - 26733006
SN - 1432-0428
VL - 59
SP - 744
EP - 754
JO - Diabetologia
JF - Diabetologia
IS - 4
ER -