Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.

Hedvig Bennet, Ines Mollet, Alexander Balhuizen, Anya Medina Benavente, Cecilia Nagorny, Annika Bagge, Joao Fadista, Emilia Ottosson Laakso, Petter Vikman, Marloes Dekker Nitert, Lena Eliasson, Nils Wierup, Isabella Artner, Malin Fex

Research output: Contribution to journalArticlepeer-review

Abstract

The Gq-coupled 5-hydroxytryptamine 2B (5-HT2B) receptor is known to regulate the proliferation of islet beta cells during pregnancy. However, the role of serotonin in the control of insulin release is still controversial. The aim of the present study was to explore the role of the 5-HT2B receptor in the regulation of insulin secretion in mouse and human islets, as well as in clonal INS-1(832/13) cells.
Original languageEnglish
Pages (from-to)744-754
JournalDiabetologia
Volume59
Issue number4
Early online date2016 Jan 6
DOIs
Publication statusPublished - 2016

Subject classification (UKÄ)

  • Endocrinology and Diabetes

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