Serotonin and adipocyte function

Malin Fex; Karin G. Stenkula

doi:10.1016/B978-0-12-800050-2.00011-5

Serotonin and adipocyte function

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Abstract

The ability to store and mobilize energy is fundamental for physiologic function. Most excess energy is stored in adipose tissue as triglycerides, which is released as free fatty acids when needed through cellular processes tightly regulated by insulin. Intact adipose cell function is essential to regulate whole-body glucose and lipid metabolism. Several studies have focused on the metabolic impact of 5-hydroxytryptamine (5-HT) on lipid metabolism and glucose homeostasis, and it has been demonstrated that circulating 5-HT, through different routes of action, exerts adipocyte-specific effects that influence both lipid- and glucose metabolism as well as cytokine secretion.

Original language	English
Title of host publication	Serotonin
Subtitle of host publication	The Mediator that Spans Evolution
Editors	Paul M Pilowsky
Publisher	Academic Press
Chapter	11
Pages	197-202
Number of pages	6
ISBN (Electronic)	9780128000502
DOIs	https://doi.org/10.1016/B978-0-12-800050-2.00011-5
Publication status	Published - 2019

Subject classification (UKÄ)

Endocrinology and Diabetes

Free keywords

5-HT
Adipocytes
Adipose tissue
Free fatty acids
Insulin signaling

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/B978-0-12-800050-2.00011-5

Cite this

@inbook{a191913237494be0a01b9da8a7bf1341,

title = "Serotonin and adipocyte function",

abstract = "The ability to store and mobilize energy is fundamental for physiologic function. Most excess energy is stored in adipose tissue as triglycerides, which is released as free fatty acids when needed through cellular processes tightly regulated by insulin. Intact adipose cell function is essential to regulate whole-body glucose and lipid metabolism. Several studies have focused on the metabolic impact of 5-hydroxytryptamine (5-HT) on lipid metabolism and glucose homeostasis, and it has been demonstrated that circulating 5-HT, through different routes of action, exerts adipocyte-specific effects that influence both lipid- and glucose metabolism as well as cytokine secretion.",

keywords = "5-HT, Adipocytes, Adipose tissue, Free fatty acids, Insulin signaling",

author = "Malin Fex and Stenkula, {Karin G.}",

year = "2019",

doi = "10.1016/B978-0-12-800050-2.00011-5",

language = "English",

pages = "197--202",

editor = "Pilowsky, {Paul M}",

booktitle = "Serotonin",

publisher = "Academic Press",

address = "United States",

}

TY - CHAP

T1 - Serotonin and adipocyte function

AU - Fex, Malin

AU - Stenkula, Karin G.

PY - 2019

Y1 - 2019

N2 - The ability to store and mobilize energy is fundamental for physiologic function. Most excess energy is stored in adipose tissue as triglycerides, which is released as free fatty acids when needed through cellular processes tightly regulated by insulin. Intact adipose cell function is essential to regulate whole-body glucose and lipid metabolism. Several studies have focused on the metabolic impact of 5-hydroxytryptamine (5-HT) on lipid metabolism and glucose homeostasis, and it has been demonstrated that circulating 5-HT, through different routes of action, exerts adipocyte-specific effects that influence both lipid- and glucose metabolism as well as cytokine secretion.

AB - The ability to store and mobilize energy is fundamental for physiologic function. Most excess energy is stored in adipose tissue as triglycerides, which is released as free fatty acids when needed through cellular processes tightly regulated by insulin. Intact adipose cell function is essential to regulate whole-body glucose and lipid metabolism. Several studies have focused on the metabolic impact of 5-hydroxytryptamine (5-HT) on lipid metabolism and glucose homeostasis, and it has been demonstrated that circulating 5-HT, through different routes of action, exerts adipocyte-specific effects that influence both lipid- and glucose metabolism as well as cytokine secretion.

KW - 5-HT

KW - Adipocytes

KW - Adipose tissue

KW - Free fatty acids

KW - Insulin signaling

UR - http://www.scopus.com/inward/record.url?scp=85080815287&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-800050-2.00011-5

DO - 10.1016/B978-0-12-800050-2.00011-5

M3 - Book chapter

SP - 197

EP - 202

BT - Serotonin

A2 - Pilowsky, Paul M

PB - Academic Press

ER -

Serotonin and adipocyte function

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this