Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease.

Huu Phuc Nguyen; Maria Björkqvist; Felix J Bode; Michael Stephan; Stephan von Hörsten

doi:10.1371/currents.RRN1190

Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease.

Huu Phuc Nguyen, Maria Björkqvist, Felix J Bode, Michael Stephan, Stephan von Hörsten

Research output: Contribution to journal › Article › peer-review

Abstract

To evaluate whether cytokines are altered in peripheral blood of rats transgenic for the human Huntington´s disease mutation we investigated serum levels of GRO/KC, IL-1β, IL-13 and TNF-α at a symptomatic stage at 12 months of age. Overall serum levels of these cytokines were not significantly changed between transgenic HD rats and controls. Moreover, we observed a high interindividual variability. Our results indicate that these cytokines will be difficult to pursue as biomarkers in at least this rat model of HD.

Original language	English
Article number	RRN1190
Journal	PLoS Currents
Volume	2
DOIs	https://doi.org/10.1371/currents.RRN1190
Publication status	Published - 2010

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Neuronal Survival (013212041)

Subject classification (UKÄ)

Neurosciences

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1371/currents.RRN1190

http://www.ncbi.nlm.nih.gov/pubmed/20981129?dopt=Abstract

Cite this

@article{08f77473f58c4e9196295c6112cbca7d,

title = "Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease.",

abstract = "To evaluate whether cytokines are altered in peripheral blood of rats transgenic for the human Huntington´s disease mutation we investigated serum levels of GRO/KC, IL-1β, IL-13 and TNF-α at a symptomatic stage at 12 months of age. Overall serum levels of these cytokines were not significantly changed between transgenic HD rats and controls. Moreover, we observed a high interindividual variability. Our results indicate that these cytokines will be difficult to pursue as biomarkers in at least this rat model of HD.",

author = "Nguyen, {Huu Phuc} and Maria Bj{\"o}rkqvist and Bode, {Felix J} and Michael Stephan and {von H{\"o}rsten}, Stephan",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)",

year = "2010",

doi = "10.1371/currents.RRN1190",

language = "English",

volume = "2",

journal = "PLoS Currents",

issn = "2157-3999",

publisher = "Public Library of Science",

}

TY - JOUR

T1 - Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease.

AU - Nguyen, Huu Phuc

AU - Björkqvist, Maria

AU - Bode, Felix J

AU - Stephan, Michael

AU - von Hörsten, Stephan

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)

PY - 2010

Y1 - 2010

N2 - To evaluate whether cytokines are altered in peripheral blood of rats transgenic for the human Huntington´s disease mutation we investigated serum levels of GRO/KC, IL-1β, IL-13 and TNF-α at a symptomatic stage at 12 months of age. Overall serum levels of these cytokines were not significantly changed between transgenic HD rats and controls. Moreover, we observed a high interindividual variability. Our results indicate that these cytokines will be difficult to pursue as biomarkers in at least this rat model of HD.

AB - To evaluate whether cytokines are altered in peripheral blood of rats transgenic for the human Huntington´s disease mutation we investigated serum levels of GRO/KC, IL-1β, IL-13 and TNF-α at a symptomatic stage at 12 months of age. Overall serum levels of these cytokines were not significantly changed between transgenic HD rats and controls. Moreover, we observed a high interindividual variability. Our results indicate that these cytokines will be difficult to pursue as biomarkers in at least this rat model of HD.

U2 - 10.1371/currents.RRN1190

DO - 10.1371/currents.RRN1190

M3 - Article

C2 - 20981129

SN - 2157-3999

VL - 2

JO - PLoS Currents

JF - PLoS Currents

M1 - RRN1190

ER -

Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease.

Abstract

Bibliographical note

Subject classification (UKÄ)

UN SDGs

Access to Document

Fingerprint

Cite this