Serum oxidized low-density lipoprotein levels are related to cardiometabolic risk and decreased after a weight loss treatment in obese children and adolescents

Lydia Morell-Azanza; Sonia García-Calzón; Tara Rendo-Urteaga; Nerea Martin-Calvo; Maria Chueca; José Alfredo Martínez; Maria Cristina Azcona-Sanjulián; Amelia Marti

doi:10.1111/pedi.12405

Serum oxidized low-density lipoprotein levels are related to cardiometabolic risk and decreased after a weight loss treatment in obese children and adolescents

Lydia Morell-Azanza, Sonia García-Calzón, Tara Rendo-Urteaga, Nerea Martin-Calvo, Maria Chueca, José Alfredo Martínez, Maria Cristina Azcona-Sanjulián, Amelia Marti

Diabetes - Epigenetics

Research output: Contribution to journal › Article › peer-review

Abstract

Background and aims: The oxidation of low-density lipoprotein (LDL) cholesterol particles is an early atherogeninic event. Obese pediatric populations have higher levels of oxidized LDL (oxLDL) than normal weight children. The aim of this study was to evaluate the effect of a weight loss program on the biochemical profile and oxLDL levels in Spanish obese children and adolescents. Methods: Forty obese children (mean age 11 years, 51% boys) followed a 10-week weight loss program. They were dichotomized at the median of body mass index-standard deviation score (BMI-SDS) change, as high (HR) and low responders (LR) after the intervention. The intervention included a moderate energy-restricted diet, nutritional education, and family involvement. Anthropometric and biochemical measurements were performed at the beginning and during the follow up. A cardiometabolic risk score (CMS) was calculated considering metabolic risk factors. Results: Higher baseline oxLDL levels were associated with a higher CMS in obese children (P

Original language	English
Pages (from-to)	392-398
Journal	Pediatric Diabetes
Volume	18
Issue number	5
Early online date	2016 Jul 20
DOIs	https://doi.org/10.1111/pedi.12405
Publication status	Published - 2017

Subject classification (UKÄ)

Endocrinology and Diabetes

Free keywords

LDL-cholesterol
BMI-SDS
Dietary intervention
Pediatrics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/pedi.12405

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Morell-Azanza, L., García-Calzón, S., Rendo-Urteaga, T., Martin-Calvo, N., Chueca, M., Martínez, J. A., Azcona-Sanjulián, M. C., & Marti, A. (2017). Serum oxidized low-density lipoprotein levels are related to cardiometabolic risk and decreased after a weight loss treatment in obese children and adolescents. Pediatric Diabetes, 18(5), 392-398. https://doi.org/10.1111/pedi.12405

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title = "Serum oxidized low-density lipoprotein levels are related to cardiometabolic risk and decreased after a weight loss treatment in obese children and adolescents",

abstract = "Background and aims: The oxidation of low-density lipoprotein (LDL) cholesterol particles is an early atherogeninic event. Obese pediatric populations have higher levels of oxidized LDL (oxLDL) than normal weight children. The aim of this study was to evaluate the effect of a weight loss program on the biochemical profile and oxLDL levels in Spanish obese children and adolescents. Methods: Forty obese children (mean age 11 years, 51% boys) followed a 10-week weight loss program. They were dichotomized at the median of body mass index-standard deviation score (BMI-SDS) change, as high (HR) and low responders (LR) after the intervention. The intervention included a moderate energy-restricted diet, nutritional education, and family involvement. Anthropometric and biochemical measurements were performed at the beginning and during the follow up. A cardiometabolic risk score (CMS) was calculated considering metabolic risk factors. Results: Higher baseline oxLDL levels were associated with a higher CMS in obese children (P",

keywords = "LDL-cholesterol, BMI-SDS, Dietary intervention, Pediatrics",

author = "Lydia Morell-Azanza and Sonia Garc{\'i}a-Calz{\'o}n and Tara Rendo-Urteaga and Nerea Martin-Calvo and Maria Chueca and Mart{\'i}nez, {Jos{\'e} Alfredo} and Azcona-Sanjuli{\'a}n, {Maria Cristina} and Amelia Marti",

year = "2017",

doi = "10.1111/pedi.12405",

language = "English",

volume = "18",

pages = "392--398",

journal = "Pediatric Diabetes",

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}

Morell-Azanza, L, García-Calzón, S, Rendo-Urteaga, T, Martin-Calvo, N, Chueca, M, Martínez, JA, Azcona-Sanjulián, MC & Marti, A 2017, 'Serum oxidized low-density lipoprotein levels are related to cardiometabolic risk and decreased after a weight loss treatment in obese children and adolescents', Pediatric Diabetes, vol. 18, no. 5, pp. 392-398. https://doi.org/10.1111/pedi.12405

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T1 - Serum oxidized low-density lipoprotein levels are related to cardiometabolic risk and decreased after a weight loss treatment in obese children and adolescents

AU - Morell-Azanza, Lydia

AU - García-Calzón, Sonia

AU - Rendo-Urteaga, Tara

AU - Martin-Calvo, Nerea

AU - Chueca, Maria

AU - Martínez, José Alfredo

AU - Azcona-Sanjulián, Maria Cristina

AU - Marti, Amelia

PY - 2017

Y1 - 2017

N2 - Background and aims: The oxidation of low-density lipoprotein (LDL) cholesterol particles is an early atherogeninic event. Obese pediatric populations have higher levels of oxidized LDL (oxLDL) than normal weight children. The aim of this study was to evaluate the effect of a weight loss program on the biochemical profile and oxLDL levels in Spanish obese children and adolescents. Methods: Forty obese children (mean age 11 years, 51% boys) followed a 10-week weight loss program. They were dichotomized at the median of body mass index-standard deviation score (BMI-SDS) change, as high (HR) and low responders (LR) after the intervention. The intervention included a moderate energy-restricted diet, nutritional education, and family involvement. Anthropometric and biochemical measurements were performed at the beginning and during the follow up. A cardiometabolic risk score (CMS) was calculated considering metabolic risk factors. Results: Higher baseline oxLDL levels were associated with a higher CMS in obese children (P

AB - Background and aims: The oxidation of low-density lipoprotein (LDL) cholesterol particles is an early atherogeninic event. Obese pediatric populations have higher levels of oxidized LDL (oxLDL) than normal weight children. The aim of this study was to evaluate the effect of a weight loss program on the biochemical profile and oxLDL levels in Spanish obese children and adolescents. Methods: Forty obese children (mean age 11 years, 51% boys) followed a 10-week weight loss program. They were dichotomized at the median of body mass index-standard deviation score (BMI-SDS) change, as high (HR) and low responders (LR) after the intervention. The intervention included a moderate energy-restricted diet, nutritional education, and family involvement. Anthropometric and biochemical measurements were performed at the beginning and during the follow up. A cardiometabolic risk score (CMS) was calculated considering metabolic risk factors. Results: Higher baseline oxLDL levels were associated with a higher CMS in obese children (P

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Serum oxidized low-density lipoprotein levels are related to cardiometabolic risk and decreased after a weight loss treatment in obese children and adolescents

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

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