Serum oxidized low-density lipoprotein levels are related to cardiometabolic risk and decreased after a weight loss treatment in obese children and adolescents

Lydia Morell-Azanza, Sonia García-Calzón, Tara Rendo-Urteaga, Nerea Martin-Calvo, Maria Chueca, José Alfredo Martínez, Maria Cristina Azcona-Sanjulián, Amelia Marti

Research output: Contribution to journalArticlepeer-review

12 Citations (SciVal)

Abstract

Background and aims: The oxidation of low-density lipoprotein (LDL) cholesterol particles is an early atherogeninic event. Obese pediatric populations have higher levels of oxidized LDL (oxLDL) than normal weight children. The aim of this study was to evaluate the effect of a weight loss program on the biochemical profile and oxLDL levels in Spanish obese children and adolescents. Methods: Forty obese children (mean age 11 years, 51% boys) followed a 10-week weight loss program. They were dichotomized at the median of body mass index-standard deviation score (BMI-SDS) change, as high (HR) and low responders (LR) after the intervention. The intervention included a moderate energy-restricted diet, nutritional education, and family involvement. Anthropometric and biochemical measurements were performed at the beginning and during the follow up. A cardiometabolic risk score (CMS) was calculated considering metabolic risk factors. Results: Higher baseline oxLDL levels were associated with a higher CMS in obese children (P

Original languageEnglish
Pages (from-to)392-398
JournalPediatric Diabetes
Volume18
Issue number5
Early online date2016 Jul 20
DOIs
Publication statusPublished - 2017

Subject classification (UKÄ)

  • Endocrinology and Diabetes

Keywords

  • LDL-cholesterol
  • BMI-SDS
  • Dietary intervention
  • Pediatrics

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