Serum sialic acid and sialoglycoproteins in asymptomatic carotid artery atherosclerosis. ARIC Investigators. Atherosclerosis Risk in Communities

Gunnar Lindberg, Lennart Råstam, Peter Nilsson-Ehle, A Lundblad, Jonas Ranstam, A R Folsom, G L Burke

Research output: Contribution to journalArticlepeer-review

13 Citations (SciVal)

Abstract

Serum total sialic acid (S-TSA) is a recently identified risk marker for atherosclerosis and cardiovascular mortality. The purpose of this study was to evaluate the influence of three sialic acid rich glycoproteins (orosomucoid, haptoglobin, and alpha1-antitrypsin) on the relationship between S-TSA and carotid atherosclerosis. The mean S-TSA was 0.045 g/l higher among cases than controls (P<0.001) in 310 45-64 year-old male and female pairs of carotid atherosclerosis cases and disease-free controls from the Atherosclerosis Risk in Communities (ARIC) Study. Also mean serum levels of the glycoproteins were significantly higher in cases compared to controls. In a conditional multiple logistic regression model with the glycoproteins as independent variables, orosomucoid was correlated most strongly with case control status. However, when incorporated into the mathematical model, S-TSA not only contributed additional information as to the risk of atherosclerosis; none of the three glycoproteins contributed further once S-TSA had been accounted for. Thus, some other source of serum sialic acid or variations in the degree of sialylation of glycoproteins may be essential for understanding the relation between S-TSA and atherosclerosis.
Original languageEnglish
Pages (from-to)65-69
JournalAtherosclerosis
Volume146
Issue number1
DOIs
Publication statusPublished - 1999

Subject classification (UKÄ)

  • Cardiac and Cardiovascular Systems

Keywords

  • Carotid atherosclerosis
  • Sialic acids
  • Orosomucoid
  • Haptoglobin
  • greek small letter alpha1-Antitrypsin
  • Human
  • Cross-sectional study

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