Sex differences in the association between body mass index and total hip or knee joint replacement resulting from osteoarthritis

Jonas Franklin, T. Ingvarsson, Martin Englund, Stefan Lohmander

Research output: Contribution to journalArticlepeer-review

38 Citations (SciVal)

Abstract

Objective: To examine the association between body mass index (BMI) and osteoarthritis (OA) leading to total hip (THR) or knee (TKR) joint replacement. Methods: Case-control study design. All patients still living in Iceland who had had a THR or TKR resulting from OA before the end of 2002 were invited to participate. First-degree relatives of participating patients served as controls. A total of 1473 patients ( 872 women) and 1103 controls ( 599 women), all born between 1910 and 1939 and who had answered a questionnaire including questions about height and weight, were analysed. A randomly selected sample, representative of the Icelandic population, was used as a secondary control group. Results: The OR, adjusted for age, occupation and presence of hand OA, for having a THR was 1.1 (95% CI 0.9 to 1.5) for overweight men and 1.7 ( 95% CI 1.0 to 2.9) for obese men. The OR for having a TKR was 1.7 ( 95% CI 1.1 to 2.6) for overweight men and 5.3 ( 95% CI 2.8 to 10.1) for obese men. The OR for having a THR was 1.0 ( 95% CI 0.8 to 1.3) for overweight women and 1.0 ( 95% CI 0.6 to 1.5) for obese women. The OR for having a TKR was 1.6 ( 95% CI 1.1 to 2.2) for overweight women and 4.0 ( 95% CI 2.6 to 6.1) for obese women. Conclusion: This study supports a positive association between high BMI and TKR in both sexes, but for THR the association with BMI seems to be weaker, and possibly negligible for women.
Original languageEnglish
Pages (from-to)536-540
JournalAnnals of the Rheumatic Diseases
Volume68
Issue number4
DOIs
Publication statusPublished - 2009

Subject classification (UKÄ)

  • Rheumatology and Autoimmunity

Fingerprint

Dive into the research topics of 'Sex differences in the association between body mass index and total hip or knee joint replacement resulting from osteoarthritis'. Together they form a unique fingerprint.

Cite this