Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions

Alexandra Epp; Juliane Hobusch; Yannic C Bartsch; Janina Petry; Gina-Maria Lilienthal; Carolien A M Koeleman; Simon Eschweiler; Christian Möbs; Ashley Hall; Suzanne C Morris; Dominique Braumann; Christine Engellenner; Josephine Bitterling; Johann Rahmöller; Alexei Leliavski; Robina Thurmann; Mattias Collin; Kelley W Moremen; Richard T Strait; Véronique Blanchard; Arnd Petersen; Timo Gemoll; Jens K Habermann; Frank Petersen; Andreas Nandy; Helga Kahlert; Michael Hertl; Manfred Wuhrer; Wolfgang Pfützner; Uta Jappe; Fred D Finkelman; Marc Ehlers

doi:10.1016/j.jaci.2017.06.021

Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions

Alexandra Epp, Juliane Hobusch, Yannic C Bartsch, Janina Petry, Gina-Maria Lilienthal, Carolien A M Koeleman, Simon Eschweiler, Christian Möbs, Ashley Hall, Suzanne C Morris, Dominique Braumann, Christine Engellenner, Josephine Bitterling, Johann Rahmöller, Alexei Leliavski, Robina Thurmann, Mattias Collin, Kelley W Moremen, Richard T Strait, Véronique BlanchardArnd Petersen, Timo Gemoll, Jens K Habermann, Frank Petersen, Andreas Nandy, Helga Kahlert, Michael Hertl, Manfred Wuhrer, Wolfgang Pfützner, Uta Jappe, Fred D Finkelman, Marc Ehlers

Research output: Contribution to journal › Letter › peer-review

Abstract

In presence of high allergen dosis besides IgE also IgG antibodies can induce allergic reactions, whose severity is dependent on the induced type of IgG Fc glycosylation, what should be considered for new AIT protocols containing new adjuvants.

Original language	English
Pages (from-to)	399-402.e8
Journal	Journal of Allergy and Clinical Immunology
Volume	141
Issue number	1
Early online date	2017 Jul 17
DOIs	https://doi.org/10.1016/j.jaci.2017.06.021
Publication status	Published - 2018

Subject classification (UKÄ)

Immunology in the Medical Area (including Cell and Immunotherapy)

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10.1016/j.jaci.2017.06.021

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Epp, A., Hobusch, J., Bartsch, Y. C., Petry, J., Lilienthal, G.-M., Koeleman, C. A. M., Eschweiler, S., Möbs, C., Hall, A., Morris, S. C., Braumann, D., Engellenner, C., Bitterling, J., Rahmöller, J., Leliavski, A., Thurmann, R., Collin, M., Moremen, K. W., Strait, R. T., ... Ehlers, M. (2018). Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions. Journal of Allergy and Clinical Immunology, 141(1), 399-402.e8. https://doi.org/10.1016/j.jaci.2017.06.021

@article{afe410db1a2e4c62b66b70e84814a4eb,

title = "Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions",

abstract = "In presence of high allergen dosis besides IgE also IgG antibodies can induce allergic reactions, whose severity is dependent on the induced type of IgG Fc glycosylation, what should be considered for new AIT protocols containing new adjuvants.",

author = "Alexandra Epp and Juliane Hobusch and Bartsch, {Yannic C} and Janina Petry and Gina-Maria Lilienthal and Koeleman, {Carolien A M} and Simon Eschweiler and Christian M{\"o}bs and Ashley Hall and Morris, {Suzanne C} and Dominique Braumann and Christine Engellenner and Josephine Bitterling and Johann Rahm{\"o}ller and Alexei Leliavski and Robina Thurmann and Mattias Collin and Moremen, {Kelley W} and Strait, {Richard T} and V{\'e}ronique Blanchard and Arnd Petersen and Timo Gemoll and Habermann, {Jens K} and Frank Petersen and Andreas Nandy and Helga Kahlert and Michael Hertl and Manfred Wuhrer and Wolfgang Pf{\"u}tzner and Uta Jappe and Finkelman, {Fred D} and Marc Ehlers",

note = "Copyright {\textcopyright} 2017. Published by Elsevier Inc.",

year = "2018",

doi = "10.1016/j.jaci.2017.06.021",

language = "English",

volume = "141",

pages = "399--402.e8",

journal = "Journal of Allergy and Clinical Immunology",

issn = "1097-6825",

publisher = "Elsevier",

number = "1",

}

Epp, A, Hobusch, J, Bartsch, YC, Petry, J, Lilienthal, G-M, Koeleman, CAM, Eschweiler, S, Möbs, C, Hall, A, Morris, SC, Braumann, D, Engellenner, C, Bitterling, J, Rahmöller, J, Leliavski, A, Thurmann, R, Collin, M, Moremen, KW, Strait, RT, Blanchard, V, Petersen, A, Gemoll, T, Habermann, JK, Petersen, F, Nandy, A, Kahlert, H, Hertl, M, Wuhrer, M, Pfützner, W, Jappe, U, Finkelman, FD & Ehlers, M 2018, 'Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions', Journal of Allergy and Clinical Immunology, vol. 141, no. 1, pp. 399-402.e8. https://doi.org/10.1016/j.jaci.2017.06.021

TY - JOUR

T1 - Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions

AU - Epp, Alexandra

AU - Hobusch, Juliane

AU - Bartsch, Yannic C

AU - Petry, Janina

AU - Lilienthal, Gina-Maria

AU - Koeleman, Carolien A M

AU - Eschweiler, Simon

AU - Möbs, Christian

AU - Hall, Ashley

AU - Morris, Suzanne C

AU - Braumann, Dominique

AU - Engellenner, Christine

AU - Bitterling, Josephine

AU - Rahmöller, Johann

AU - Leliavski, Alexei

AU - Thurmann, Robina

AU - Collin, Mattias

AU - Moremen, Kelley W

AU - Strait, Richard T

AU - Blanchard, Véronique

AU - Petersen, Arnd

AU - Gemoll, Timo

AU - Habermann, Jens K

AU - Petersen, Frank

AU - Nandy, Andreas

AU - Kahlert, Helga

AU - Hertl, Michael

AU - Wuhrer, Manfred

AU - Pfützner, Wolfgang

AU - Jappe, Uta

AU - Finkelman, Fred D

AU - Ehlers, Marc

PY - 2018

Y1 - 2018

N2 - In presence of high allergen dosis besides IgE also IgG antibodies can induce allergic reactions, whose severity is dependent on the induced type of IgG Fc glycosylation, what should be considered for new AIT protocols containing new adjuvants.

AB - In presence of high allergen dosis besides IgE also IgG antibodies can induce allergic reactions, whose severity is dependent on the induced type of IgG Fc glycosylation, what should be considered for new AIT protocols containing new adjuvants.

U2 - 10.1016/j.jaci.2017.06.021

DO - 10.1016/j.jaci.2017.06.021

M3 - Letter

C2 - 28728998

SN - 1097-6825

VL - 141

SP - 399-402.e8

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 1

ER -

Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions

Abstract

Subject classification (UKÄ)

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