Signal Transduction and Gene Regulation in Cerebral Arteries Following Ischemia

Petter Vikman

Signal Transduction and Gene Regulation in Cerebral Arteries Following Ischemia

Petter Vikman

Medicine, Lund

Research output: Thesis › Doctoral Thesis (compilation)

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Abstract

The thesis consideres the molecular events that take place in the cerebral arteries following a stroke. The degree and temporal course of reperfusion following a stroke is pivotal for the survival of the neuronal tissue in the penumbra. Previous investigations have revealed upregulation of contractile receptors, a putative factor in the blood flow reduction following stroke that can could augment cell death. The major aim of the study is achieve a better understanding of the changes that occur in the cerebral arteries following a stroke and of the resulting activation of the signal pathways involved, along with changes in gene expression and protein regulation to further the knowledge of how arteries participate in the events that take place following a stroke.

The more specific goals have been the following:

* To investigate the gene regulation in cerebral arteries following SAH, aimed at determining what the important processes involved in the increase in contraction are.

* Investigation of MAPK activation and its relation to gene expression.

* Comparison of the ischemic models MCAO and SAH with organ culture of cerebral arteries to determine similarities and to validate the use of organ culture as a model.

* Investigation of gene expression and protein regulation in human MCA following thromboembolic stroke so as validate previous findings in connection with experimental rat models.

* Molecular characterization of smoke induced changes in cerebral arteries.

Original language	English
Qualification	Doctor
Awarding Institution	Medicine, Lund
Supervisors/Advisors	Edvinsson, Lars, Supervisor
Award date	2006 Jun 16
Publisher	Experimental Vascular Research
ISBN (Print)	91-85559-11-3
Publication status	Published - 2006

Bibliographical note

Defence details

Date: 2006-06-16
Time: 09:00
Place: Segerfalk salen BMC

External reviewer(s)

Name: Kelly, Paul
Title: BSc, PhD
Affiliation: Western General Hospital, Edinburgh

---

<div class="article_info">P Vikman, S Beg, T Khurana, J Hansen-Schwartz and L Edvinsson. <span class="article_issue_date">2006</span>. <span class="article_title">Gene expression and molecular changes in cerebral arteries following subarachnoid hemorrhage in rat.</span> <span class="journal_series_title">Journal of Neurosurgery</span>, (accepted)</div>
<div class="article_info">P Vikman and L Edvinsson. <span class="article_issue_date">2006</span>. <span class="article_title">Gene expression profiling in the human middle cerebral artery after cerebral ischemia.</span> <span class="journal_series_title">European Journal of Neurology</span>, (accepted)</div>
<div class="article_info">P Vikman, S Beg, M Henriksson and L Edvinsson. <span class="article_issue_date">2006</span>. <span class="article_title">Activation of p38, ERK1/2 and SAPK/JNK initiate transcription of inflammatory and extracellular matrix genes in cerebral arteries following cerebral ischemia in rat.</span> (submitted)</div>
<div class="article_info">P Vikman, S Beg and L Edvinsson. <span class="article_issue_date">2006</span>. <span class="article_title">Signal transduction, inflammation and gene activation in cerebral arteries following experimental SAH in rat.</span> (submitted)</div>
<div class="article_info">P Vikman and L Edvinsson. <span class="article_issue_date">2006</span>. <span class="article_title">Lipid soluble smoking particles induce an inflammatory response in rat cerebral arteries via p38MAPK activation and downstream transcription factors ATF-2 and Elk-1.</span> (submitted)</div>

Subject classification (UKÄ)

Other Clinical Medicine

Free keywords

Naturvetenskap
Cardiovascular system
stroke
molecular investigation
gene expression
Mitogen Activated Protein Kinases
Natural science
Kardiovaskulära systemet
cerebral arteries

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P_Vikman_kappa

Cite this

@phdthesis{ab94bfd5fe3a4b6fbe79583558d4f54a,

title = "Signal Transduction and Gene Regulation in Cerebral Arteries Following Ischemia",

abstract = "The thesis consideres the molecular events that take place in the cerebral arteries following a stroke. The degree and temporal course of reperfusion following a stroke is pivotal for the survival of the neuronal tissue in the penumbra. Previous investigations have revealed upregulation of contractile receptors, a putative factor in the blood flow reduction following stroke that can could augment cell death. The major aim of the study is achieve a better understanding of the changes that occur in the cerebral arteries following a stroke and of the resulting activation of the signal pathways involved, along with changes in gene expression and protein regulation to further the knowledge of how arteries participate in the events that take place following a stroke. The more specific goals have been the following: * To investigate the gene regulation in cerebral arteries following SAH, aimed at determining what the important processes involved in the increase in contraction are. * Investigation of MAPK activation and its relation to gene expression. * Comparison of the ischemic models MCAO and SAH with organ culture of cerebral arteries to determine similarities and to validate the use of organ culture as a model. * Investigation of gene expression and protein regulation in human MCA following thromboembolic stroke so as validate previous findings in connection with experimental rat models. * Molecular characterization of smoke induced changes in cerebral arteries.",

keywords = "Naturvetenskap, Cardiovascular system, stroke, molecular investigation, gene expression, Mitogen Activated Protein Kinases, Natural science, Kardiovaskul{\"a}ra systemet, cerebral arteries",

author = "Petter Vikman",

note = "Defence details Date: 2006-06-16 Time: 09:00 Place: Segerfalk salen BMC External reviewer(s) Name: Kelly, Paul Title: BSc, PhD Affiliation: Western General Hospital, Edinburgh --- <div class={"}article_info{"}>P Vikman, S Beg, T Khurana, J Hansen-Schwartz and L Edvinsson. <span class={"}article_issue_date{"}>2006</span>. <span class={"}article_title{"}>Gene expression and molecular changes in cerebral arteries following subarachnoid hemorrhage in rat.</span> <span class={"}journal_series_title{"}>Journal of Neurosurgery</span>, (accepted)</div> <div class={"}article_info{"}>P Vikman and L Edvinsson. <span class={"}article_issue_date{"}>2006</span>. <span class={"}article_title{"}>Gene expression profiling in the human middle cerebral artery after cerebral ischemia.</span> <span class={"}journal_series_title{"}>European Journal of Neurology</span>, (accepted)</div> <div class={"}article_info{"}>P Vikman, S Beg, M Henriksson and L Edvinsson. <span class={"}article_issue_date{"}>2006</span>. <span class={"}article_title{"}>Activation of p38, ERK1/2 and SAPK/JNK initiate transcription of inflammatory and extracellular matrix genes in cerebral arteries following cerebral ischemia in rat.</span> (submitted)</div> <div class={"}article_info{"}>P Vikman, S Beg and L Edvinsson. <span class={"}article_issue_date{"}>2006</span>. <span class={"}article_title{"}>Signal transduction, inflammation and gene activation in cerebral arteries following experimental SAH in rat.</span> (submitted)</div> <div class={"}article_info{"}>P Vikman and L Edvinsson. <span class={"}article_issue_date{"}>2006</span>. <span class={"}article_title{"}>Lipid soluble smoking particles induce an inflammatory response in rat cerebral arteries via p38MAPK activation and downstream transcription factors ATF-2 and Elk-1.</span> (submitted)</div>",

year = "2006",

language = "English",

isbn = "91-85559-11-3",

publisher = "Experimental Vascular Research",

type = "Doctoral Thesis (compilation)",

school = "Medicine, Lund",

}

TY - THES

T1 - Signal Transduction and Gene Regulation in Cerebral Arteries Following Ischemia

AU - Vikman, Petter

N1 - Defence details Date: 2006-06-16 Time: 09:00 Place: Segerfalk salen BMC External reviewer(s) Name: Kelly, Paul Title: BSc, PhD Affiliation: Western General Hospital, Edinburgh --- <div class="article_info">P Vikman, S Beg, T Khurana, J Hansen-Schwartz and L Edvinsson. <span class="article_issue_date">2006</span>. <span class="article_title">Gene expression and molecular changes in cerebral arteries following subarachnoid hemorrhage in rat.</span> <span class="journal_series_title">Journal of Neurosurgery</span>, (accepted)</div> <div class="article_info">P Vikman and L Edvinsson. <span class="article_issue_date">2006</span>. <span class="article_title">Gene expression profiling in the human middle cerebral artery after cerebral ischemia.</span> <span class="journal_series_title">European Journal of Neurology</span>, (accepted)</div> <div class="article_info">P Vikman, S Beg, M Henriksson and L Edvinsson. <span class="article_issue_date">2006</span>. <span class="article_title">Activation of p38, ERK1/2 and SAPK/JNK initiate transcription of inflammatory and extracellular matrix genes in cerebral arteries following cerebral ischemia in rat.</span> (submitted)</div> <div class="article_info">P Vikman, S Beg and L Edvinsson. <span class="article_issue_date">2006</span>. <span class="article_title">Signal transduction, inflammation and gene activation in cerebral arteries following experimental SAH in rat.</span> (submitted)</div> <div class="article_info">P Vikman and L Edvinsson. <span class="article_issue_date">2006</span>. <span class="article_title">Lipid soluble smoking particles induce an inflammatory response in rat cerebral arteries via p38MAPK activation and downstream transcription factors ATF-2 and Elk-1.</span> (submitted)</div>

PY - 2006

Y1 - 2006

N2 - The thesis consideres the molecular events that take place in the cerebral arteries following a stroke. The degree and temporal course of reperfusion following a stroke is pivotal for the survival of the neuronal tissue in the penumbra. Previous investigations have revealed upregulation of contractile receptors, a putative factor in the blood flow reduction following stroke that can could augment cell death. The major aim of the study is achieve a better understanding of the changes that occur in the cerebral arteries following a stroke and of the resulting activation of the signal pathways involved, along with changes in gene expression and protein regulation to further the knowledge of how arteries participate in the events that take place following a stroke. The more specific goals have been the following: * To investigate the gene regulation in cerebral arteries following SAH, aimed at determining what the important processes involved in the increase in contraction are. * Investigation of MAPK activation and its relation to gene expression. * Comparison of the ischemic models MCAO and SAH with organ culture of cerebral arteries to determine similarities and to validate the use of organ culture as a model. * Investigation of gene expression and protein regulation in human MCA following thromboembolic stroke so as validate previous findings in connection with experimental rat models. * Molecular characterization of smoke induced changes in cerebral arteries.

AB - The thesis consideres the molecular events that take place in the cerebral arteries following a stroke. The degree and temporal course of reperfusion following a stroke is pivotal for the survival of the neuronal tissue in the penumbra. Previous investigations have revealed upregulation of contractile receptors, a putative factor in the blood flow reduction following stroke that can could augment cell death. The major aim of the study is achieve a better understanding of the changes that occur in the cerebral arteries following a stroke and of the resulting activation of the signal pathways involved, along with changes in gene expression and protein regulation to further the knowledge of how arteries participate in the events that take place following a stroke. The more specific goals have been the following: * To investigate the gene regulation in cerebral arteries following SAH, aimed at determining what the important processes involved in the increase in contraction are. * Investigation of MAPK activation and its relation to gene expression. * Comparison of the ischemic models MCAO and SAH with organ culture of cerebral arteries to determine similarities and to validate the use of organ culture as a model. * Investigation of gene expression and protein regulation in human MCA following thromboembolic stroke so as validate previous findings in connection with experimental rat models. * Molecular characterization of smoke induced changes in cerebral arteries.

KW - Naturvetenskap

KW - Cardiovascular system

KW - stroke

KW - molecular investigation

KW - gene expression

KW - Mitogen Activated Protein Kinases

KW - Natural science

KW - Kardiovaskulära systemet

KW - cerebral arteries

M3 - Doctoral Thesis (compilation)

SN - 91-85559-11-3

PB - Experimental Vascular Research

ER -

Signal Transduction and Gene Regulation in Cerebral Arteries Following Ischemia

Abstract

Bibliographical note

Subject classification (UKÄ)

Free keywords

Access to Document

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Cite this