Signal Transduction and Gene Regulation in Cerebral Arteries Following Ischemia

Petter Vikman

Research output: ThesisDoctoral Thesis (compilation)

332 Downloads (Pure)

Abstract

The thesis consideres the molecular events that take place in the cerebral arteries following a stroke. The degree and temporal course of reperfusion following a stroke is pivotal for the survival of the neuronal tissue in the penumbra. Previous investigations have revealed upregulation of contractile receptors, a putative factor in the blood flow reduction following stroke that can could augment cell death. The major aim of the study is achieve a better understanding of the changes that occur in the cerebral arteries following a stroke and of the resulting activation of the signal pathways involved, along with changes in gene expression and protein regulation to further the knowledge of how arteries participate in the events that take place following a stroke.

The more specific goals have been the following:

* To investigate the gene regulation in cerebral arteries following SAH, aimed at determining what the important processes involved in the increase in contraction are.

* Investigation of MAPK activation and its relation to gene expression.

* Comparison of the ischemic models MCAO and SAH with organ culture of cerebral arteries to determine similarities and to validate the use of organ culture as a model.

* Investigation of gene expression and protein regulation in human MCA following thromboembolic stroke so as validate previous findings in connection with experimental rat models.

* Molecular characterization of smoke induced changes in cerebral arteries.
Original languageEnglish
QualificationDoctor
Awarding Institution
  • Medicine, Lund
Supervisors/Advisors
  • Edvinsson, Lars, Supervisor
Award date2006 Jun 16
Publisher
ISBN (Print)91-85559-11-3
Publication statusPublished - 2006

Bibliographical note

Defence details

Date: 2006-06-16
Time: 09:00
Place: Segerfalk salen BMC

External reviewer(s)

Name: Kelly, Paul
Title: BSc, PhD
Affiliation: Western General Hospital, Edinburgh

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<div class="article_info">P Vikman, S Beg, T Khurana, J Hansen-Schwartz and L Edvinsson. <span class="article_issue_date">2006</span>. <span class="article_title">Gene expression and molecular changes in cerebral arteries following subarachnoid hemorrhage in rat.</span> <span class="journal_series_title">Journal of Neurosurgery</span>, (accepted)</div>
<div class="article_info">P Vikman and L Edvinsson. <span class="article_issue_date">2006</span>. <span class="article_title">Gene expression profiling in the human middle cerebral artery after cerebral ischemia.</span> <span class="journal_series_title">European Journal of Neurology</span>, (accepted)</div>
<div class="article_info">P Vikman, S Beg, M Henriksson and L Edvinsson. <span class="article_issue_date">2006</span>. <span class="article_title">Activation of p38, ERK1/2 and SAPK/JNK initiate transcription of inflammatory and extracellular matrix genes in cerebral arteries following cerebral ischemia in rat.</span> (submitted)</div>
<div class="article_info">P Vikman, S Beg and L Edvinsson. <span class="article_issue_date">2006</span>. <span class="article_title">Signal transduction, inflammation and gene activation in cerebral arteries following experimental SAH in rat.</span> (submitted)</div>
<div class="article_info">P Vikman and L Edvinsson. <span class="article_issue_date">2006</span>. <span class="article_title">Lipid soluble smoking particles induce an inflammatory response in rat cerebral arteries via p38MAPK activation and downstream transcription factors ATF-2 and Elk-1.</span> (submitted)</div>

Subject classification (UKÄ)

  • Other Clinical Medicine

Free keywords

  • Naturvetenskap
  • Cardiovascular system
  • stroke
  • molecular investigation
  • gene expression
  • Mitogen Activated Protein Kinases
  • Natural science
  • Kardiovaskulära systemet
  • cerebral arteries

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