Simple model for the growth behaviour of mixed lecithin-bile salt micelles

Dilek Madenci, Anniina Salonen, Peter Schurtenberger, Jan Skov Pedersen, Stefan U. Egelhaaf

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32 Citations (SciVal)

Abstract

Mixed lecithin-bile salt micelles are known to have a cylindrical or worm-like structure. We investigated their shape, length, flexibility and cross-sectional structure using small-angle neutron scattering (SANS). A broad range of sample compositions was studied varying both the total amphiphile concentration and the molar ratio of bile salt (sodium taurochenodeoxycholate, NaTCDC) to lecithin (egg yolk phosphatidylcholine, EYL). The length of the micelles was quantitatively linked to the micellar composition by introducing a simple model. The model takes into account the partitioning of lecithin and bile salt between the bulk, cylindrical parts and the end caps of the micelles. The model also sheds light on the organization of the micelles, both in their cylindrical regions and end caps.
Original languageEnglish
Pages (from-to)3171-3178
JournalPhysical Chemistry Chemical Physics
Volume13
Issue number8
DOIs
Publication statusPublished - 2011

Subject classification (UKÄ)

  • Physical Chemistry

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