Simulated Mid-ranging Control of Propofol and Remifentanil using EEG-measured Hypnotic Depth of Anesthesia

Kristian Soltesz; Guy A. Dumont; Klaske van Heusden; Tore Hägglund; J. Mark Ansermino

doi:10.1109/CDC.2012.6426858

Simulated Mid-ranging Control of Propofol and Remifentanil using EEG-measured Hypnotic Depth of Anesthesia

Kristian Soltesz, Guy A. Dumont, Klaske van Heusden, Tore Hägglund, J. Mark Ansermino

Research output: Chapter in Book/Report/Conference proceeding › Paper in conference proceeding › peer-review

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Abstract

This paper suggests an extension of an existing, clinically evaluated, closed-loop drug delivery system for hypnotic depth control using propofol. The extension introduces closed-loop administration of the analgesic drug remifentanil, thus forming a multiple input–single output (MISO) control system. Remifentanil acts and is metabolized at a significantly faster time scale than propofol. Direct control of analgesia is hindered by the current absence of a reliable real-time nociception monitor. However, several hypnotic depth monitors respond to nociception. Sudden changes in the measured hypnotic depth are frequently caused by changes in noxious stimulation. The novelty of this work lies in increasing the disturbance rejection bandwidth of the control system for hypnotic depth by directing the high frequency content of its control error to a remifentanil controller. Such a mid-ranging control system was implemented and tuned based on 23 patient models obtained from a previous clinical study and its performance is demonstrated through a simulation study.

Original language	English
Title of host publication	51st IEEE Conference on Decision and Control
Publisher	IEEE - Institute of Electrical and Electronics Engineers Inc.
Pages	356-361
ISBN (Print)	978-1-4673-2064-1
DOIs	https://doi.org/10.1109/CDC.2012.6426858
Publication status	Published - 2012
Event	51st IEEE Conference on Decision and Control, 2012 - Maui, Hawaii, Maui, Hawaii, United States Duration: 2012 Dec 10 → 2012 Dec 13 Conference number: 51 http://www.ieeecss.org/CAB/conferences/cdc2012/

Publication series

Name
ISSN (Print)	0191-2216

Conference

Conference	51st IEEE Conference on Decision and Control, 2012
Abbreviated title	cdc2012
Country/Territory	United States
City	Maui, Hawaii
Period	2012/12/10 → 2012/12/13
Internet address	http://www.ieeecss.org/CAB/conferences/cdc2012/

Subject classification (UKÄ)

Control Engineering

Free keywords

Medical control systems
Drug delivery
Control system synthesis
Medical simulation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1109/CDC.2012.6426858

soltesz12cAccepted author manuscript, 1.13 MB

Anesthesia in Closed Loop
Soltesz, K. (PI), Troeng, O. (Research student), Bagge Carlson, F. (Research student) & Cervin, A. (Researcher)
2011/01/01 → 2020/01/01
Project: Research
LCCC
Holmqvist, A. (Researcher), Andersson, N. (Researcher), Cervin, A. (Researcher), Mannesson, A. (Researcher), Gattami, A. (Researcher), Ghulchak, A. (Researcher), Papadopoulos, A. V. (Researcher), Rantzer, A. (Researcher), Robertsson, A. (Researcher), Sootla, A. (Researcher), THEORIN, A. (Researcher), Bernhardsson, B. (Researcher), Olofsson, B. (Researcher), Wittenmark, B. (Researcher), Grussler, C. (Researcher), Johnsson, C. (Researcher), MADJIDIAN, D. (Researcher), Johannesson, E. (Researcher), Magnusson, F. (Researcher), Ståhl, F. (Researcher), Como, G. (Researcher), Chasparis, G. (Researcher), Turesson, G. (Researcher), Dressler, I. (Researcher), Åkesson, J. (Researcher), Cho, J. H. (Researcher), Årzén, K.-E. (Researcher), Åström, K. J. (Researcher), Sou, K. C. (Researcher), Mårtensson, K. (Researcher), Berntorp, K. (Researcher), Soltesz, K. (Researcher), Lessard, L. (Researcher), Hast, M. (Researcher), Rönn, M. (Researcher), Ansbjerg Kjær, M. (Researcher), Maggio, M. (Researcher), Kristalny, M. (Researcher), Garpinger, O. (Researcher), From, P. J. (Researcher), Larsson, P.-O. (Researcher), Giselsson, P. (Researcher), Johansson, R. (Researcher), Hägglund, T. (Researcher), Vladimerou, V. (Researcher), Romero Segovia, V. (Researcher), Aurelius, A. (Researcher), Cedersjö, G. (Researcher), Bür, K. (Researcher), Dellkrantz, M. (Researcher), Du, M. (Researcher), Amani, P. (Researcher), Larsson, R. (Researcher), Tärneberg, W. (Research student), Li, Z. (Researcher), Yin, L. (Researcher), Tufvesson, F. (Researcher), Höst, S. (Researcher), Nilsson, B. (Researcher), Stenström, S. (Researcher), Andersson, J. A. (Researcher), Diehl, S. (Researcher), Dürango, J. (Researcher), Ghazaei Ardakani, M. (Researcher), Forsberg, P.-O. (Researcher), Bengtsson, F. (Researcher), Jörntell, H. (Researcher), Arévalo, C. (Researcher), Führer, C. (Researcher), Andersson, C. (Researcher), Mohammadi, F. (Researcher), Ödling, P. (Researcher), Andersson, M. (Researcher), Kihl, M. (Researcher) & Tunestål, P. (Researcher)
2008/07/01 → 2018/06/30
Project: Research

Cite this

@inproceedings{0b71d0f9cc4949ffbc1eb63d037c444e,

title = "Simulated Mid-ranging Control of Propofol and Remifentanil using EEG-measured Hypnotic Depth of Anesthesia",

abstract = "This paper suggests an extension of an existing, clinically evaluated, closed-loop drug delivery system for hypnotic depth control using propofol. The extension introduces closed-loop administration of the analgesic drug remifentanil, thus forming a multiple input–single output (MISO) control system. Remifentanil acts and is metabolized at a significantly faster time scale than propofol. Direct control of analgesia is hindered by the current absence of a reliable real-time nociception monitor. However, several hypnotic depth monitors respond to nociception. Sudden changes in the measured hypnotic depth are frequently caused by changes in noxious stimulation. The novelty of this work lies in increasing the disturbance rejection bandwidth of the control system for hypnotic depth by directing the high frequency content of its control error to a remifentanil controller. Such a mid-ranging control system was implemented and tuned based on 23 patient models obtained from a previous clinical study and its performance is demonstrated through a simulation study.",

keywords = "Medical control systems, Drug delivery, Control system synthesis, Medical simulation",

author = "Kristian Soltesz and Dumont, {Guy A.} and {van Heusden}, Klaske and Tore H{\"a}gglund and Ansermino, {J. Mark}",

year = "2012",

doi = "10.1109/CDC.2012.6426858",

language = "English",

isbn = "978-1-4673-2064-1",

publisher = "IEEE - Institute of Electrical and Electronics Engineers Inc.",

pages = "356--361",

booktitle = "51st IEEE Conference on Decision and Control",

address = "United States",

note = "51st IEEE Conference on Decision and Control, 2012, cdc2012 ; Conference date: 10-12-2012 Through 13-12-2012",

url = "http://www.ieeecss.org/CAB/conferences/cdc2012/",

}

Soltesz, K, Dumont, GA, van Heusden, K, Hägglund, T & Ansermino, JM 2012, Simulated Mid-ranging Control of Propofol and Remifentanil using EEG-measured Hypnotic Depth of Anesthesia. in 51st IEEE Conference on Decision and Control. IEEE - Institute of Electrical and Electronics Engineers Inc., pp. 356-361, 51st IEEE Conference on Decision and Control, 2012, Maui, Hawaii, United States, 2012/12/10. https://doi.org/10.1109/CDC.2012.6426858

Simulated Mid-ranging Control of Propofol and Remifentanil using EEG-measured Hypnotic Depth of Anesthesia. / Soltesz, Kristian; Dumont, Guy A.; van Heusden, Klaske et al.
51st IEEE Conference on Decision and Control. IEEE - Institute of Electrical and Electronics Engineers Inc., 2012. p. 356-361.

Research output: Chapter in Book/Report/Conference proceeding › Paper in conference proceeding › peer-review

TY - GEN

T1 - Simulated Mid-ranging Control of Propofol and Remifentanil using EEG-measured Hypnotic Depth of Anesthesia

AU - Soltesz, Kristian

AU - Dumont, Guy A.

AU - van Heusden, Klaske

AU - Hägglund, Tore

AU - Ansermino, J. Mark

N1 - Conference code: 51

PY - 2012

Y1 - 2012

N2 - This paper suggests an extension of an existing, clinically evaluated, closed-loop drug delivery system for hypnotic depth control using propofol. The extension introduces closed-loop administration of the analgesic drug remifentanil, thus forming a multiple input–single output (MISO) control system. Remifentanil acts and is metabolized at a significantly faster time scale than propofol. Direct control of analgesia is hindered by the current absence of a reliable real-time nociception monitor. However, several hypnotic depth monitors respond to nociception. Sudden changes in the measured hypnotic depth are frequently caused by changes in noxious stimulation. The novelty of this work lies in increasing the disturbance rejection bandwidth of the control system for hypnotic depth by directing the high frequency content of its control error to a remifentanil controller. Such a mid-ranging control system was implemented and tuned based on 23 patient models obtained from a previous clinical study and its performance is demonstrated through a simulation study.

AB - This paper suggests an extension of an existing, clinically evaluated, closed-loop drug delivery system for hypnotic depth control using propofol. The extension introduces closed-loop administration of the analgesic drug remifentanil, thus forming a multiple input–single output (MISO) control system. Remifentanil acts and is metabolized at a significantly faster time scale than propofol. Direct control of analgesia is hindered by the current absence of a reliable real-time nociception monitor. However, several hypnotic depth monitors respond to nociception. Sudden changes in the measured hypnotic depth are frequently caused by changes in noxious stimulation. The novelty of this work lies in increasing the disturbance rejection bandwidth of the control system for hypnotic depth by directing the high frequency content of its control error to a remifentanil controller. Such a mid-ranging control system was implemented and tuned based on 23 patient models obtained from a previous clinical study and its performance is demonstrated through a simulation study.

KW - Medical control systems

KW - Drug delivery

KW - Control system synthesis

KW - Medical simulation

U2 - 10.1109/CDC.2012.6426858

DO - 10.1109/CDC.2012.6426858

M3 - Paper in conference proceeding

SN - 978-1-4673-2064-1

SP - 356

EP - 361

BT - 51st IEEE Conference on Decision and Control

PB - IEEE - Institute of Electrical and Electronics Engineers Inc.

T2 - 51st IEEE Conference on Decision and Control, 2012

Y2 - 10 December 2012 through 13 December 2012

ER -

Simulated Mid-ranging Control of Propofol and Remifentanil using EEG-measured Hypnotic Depth of Anesthesia

Abstract

Publication series

Conference

Subject classification (UKÄ)

Free keywords

UN SDGs

Access to Document

Fingerprint

Projects

Anesthesia in Closed Loop

LCCC

Cite this