Abstract
We describe a novel cell culture protocol for the generation of neurons from a human teratocarcinoma cell line. These neurons were used to investigate hypoxic-ischaemic cell damage and for developing neuroprotective strategies. Cultures of human model neurons should eventually serve to reduce the number of experimental animals in cerebral stroke research.
| Original language | English |
|---|---|
| Pages (from-to) | 16-18 |
| Journal | ALTEX Alternatives To Animal Experimentation |
| Volume | 24 |
| Publication status | Published - 2007 |
Subject classification (UKÄ)
- Ophthalmology
Free keywords
- reduction
- organ-specific
- brain-cell cultures
- human
- neuroprotection
- neural differentiation
- ischaemia
- excitotoxicity
- glutamate
- replacement
- pharmacological testing