Simultaneous and rate-coordinated conversion of lignocellulose derived glucose, xylose, arabinose, mannose, and galactose into D-lactic acid production facilitates D-lactide synthesis

Niling He, Mingxing Chen, Zhongyang Qiu, Chun Fang, Gunnar Lidén, Xiucai Liu, Bin Zhang, Jie Bao

Research output: Contribution to journalArticlepeer-review

Abstract

D-lactide is the precursor of poly(D-lactide) (PDLA) or stereo-complex with poly(L-lactide) (PLLA). Lignocellulosic biomass provides the essential feedstock option to synthesize D-lactic acid and D-lactide. The residual sugars in D-lactic acid fermentation broth significantly blocks the D-lactide synthesis. This study showed a simultaneous and rate-coordinated conversion of lignocellulose derived glucose, xylose, arabinose, mannose, and galactose into D-lactic acid by adaptively evolved Pediococcus acidilactici ZY271 by simultaneous saccharification and co-fermentation (SSCF) of wheat straw. The produced D-lactic acid achieved minimum residual sugars (∼1.7 g/L), high chirality (∼99.1%) and high titer (∼128 g/L). A dry acid pretreatment eliminated the wastewater stream generation and the biodetoxification by fungus Amorphotheca resinae ZN1 removed the inhibitors from the pretreatment. The removal of the sugar residues and inhibitor impurities in D-lactic acid production from lignocellulose strongly facilitated the D-lactide synthesis. This study filled the gap in cellulosic D-lactide production from lignocellulose-derived D-lactic acid.

Original languageEnglish
Article number128950
JournalBioresource Technology
Volume377
DOIs
Publication statusPublished - 2023

Subject classification (UKÄ)

  • Biochemistry and Molecular Biology
  • Organic Chemistry

Free keywords

  • Biodetoxification
  • D-lactic acid
  • D-lactide
  • Lignocellulosic biomass
  • Pediococcus acidilactici

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