Abstract
Apolipoprotein A-I (apoA-I), the main protein constituent of HDL, has a central role in the reverse cholesterol-transport pathway, which together with the anti-inflammatory properties of apoA-I/HDL provide cardioprotection. Recent findings of direct stimulation of glucose uptake in muscle by apoA-I/HDL suggest that altered apoA-I and HDL functionality may be a contributing factor to the development of diabetes. We have studied the in vivo effects of short treatments with human apoA-I in a high-fat diet fed mouse model. In addition to native apoA-I, we investigated the effects of the cardioprotective Milano variant (Arg173Cys).
Original language | English |
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Pages (from-to) | 797-800 |
Journal | Diabetologia |
Volume | 57 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2014 |
Subject classification (UKÄ)
- Endocrinology and Diabetes