Size-dependent lymphatic uptake of nanoscale-tailored particles as tumor mass increases

Pontus Kjellman, Sarah Fredriksson, Christian Kjellman, Sven-Erik Strand, René In 't Zandt

Research output: Contribution to journalArticlepeer-review

Abstract

AIM: To investigate the size-dependent lymphatic uptake of nanoparticles in mice with rapidly growing syngeneic tumors.

MATERIALS & METHODS: Mice were inoculated subcutaneously with EL4 lymphoma cells and on day 5 or day 6 of tumor growth, injected peritumorally with either 29 nm or 58 nm of ultra-small superparamagnetic iron oxide nanoparticles. Twenty-four hours later the animals were imaged using MRI.

RESULTS & CONCLUSION: The larger of the two particles can only be detected in the lymph node when injected in animals with 6-day-old tumors while the 29 nm ultra-small superparamagnetic iron oxide nanoparticle is observed on both time points. Tumor mass greatly impacts the size of particles that are transported to the lymph nodes.

Original languageEnglish
Article numberFSO60
JournalFuture science OA
Volume1
Issue number4
DOIs
Publication statusPublished - 2015 Nov

Subject classification (UKÄ)

  • Radiology, Nuclear Medicine and Medical Imaging

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