Skin application of glutathione and iron sulfate can inhibit elicitation of allergic contact dermatitis from hexavalent chromium

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Allergic contact dermatitis (ACD) caused by hexavalent chromium, Cr(VI), is often severe and difficult to treat. The most common source of exposure to Cr(VI) in Sweden used to be cement, and more recently leather. The contact allergy can be diminished or inhibited if the exposure is decreased or ceases. Barrier creams against different kinds of allergens have been investigated for their protective properties which may offer protection against Cr(VI) exposure. Objectives: To investigate the capacity of formulas containing glutathione (GSH) and iron sulfate to inhibit elicitation of ACD in Cr(VI)-allergic individuals when exposed to Cr(VI). Methods: In 18 Cr(VI)-allergic volunteers the back was divided into eight patch test areas which were treated with preparations of possible barrier creams, prior to patch testing with a dilution series of potassium dichromate and a buffered extract of cement. Results: A significant reduction in reactivity to Cr(VI) and cement extract on skin treated with formulas containing GSH or iron sulfate was noticed, compared with untreated skin. Conclusion: Formulas containing GSH or iron sulfate in barrier creams inhibit ACD in individuals allergic to Cr(VI) when applied before exposure to Cr(VI) and cement extract.

Original languageEnglish
Pages (from-to)45-53
JournalContact Dermatitis
Volume82
Issue number1
Early online date2019 Oct 4
DOIs
Publication statusPublished - 2020

Subject classification (UKÄ)

  • Dermatology and Venereal Diseases

Free keywords

  • allergic contact dermatitis
  • barrier cream
  • chromate
  • contact allergy
  • Cr(III)
  • Cr(VI)
  • delayed hypersensitivity
  • hexavalent chromium
  • patch testing
  • prevention
  • trivalent chromium

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