TY - JOUR
T1 - Smoking as a risk factor for myelodysplastic syndromes and acute myeloid leukemia and its relation to cytogenetic findings: A case-control study.
AU - Björk, Jonas
AU - Johansson, Bertil
AU - Broberg Palmgren, Karin
AU - Albin, Maria
PY - 2009
Y1 - 2009
N2 - In this case-control study, interview data on smoking habits were available for 179 de novo cases (116 with cytogenetic data) of acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). Smoking habits were compared with a pooled set of population controls and hospital controls (diagnosed with malignant melanoma). Each pack-year of smoking increased the risk of MDS with 1.3% (95% CI 0.1-2.6%), corresponding to an estimated excess risk of 71% (95% CI 3-180%) for 40 pack-years. Associations between smoking and the specific aberrations -5/5q-, -7/7q-, and +8 in AML and MDS were indicated but the estimates were imprecise.
AB - In this case-control study, interview data on smoking habits were available for 179 de novo cases (116 with cytogenetic data) of acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). Smoking habits were compared with a pooled set of population controls and hospital controls (diagnosed with malignant melanoma). Each pack-year of smoking increased the risk of MDS with 1.3% (95% CI 0.1-2.6%), corresponding to an estimated excess risk of 71% (95% CI 3-180%) for 40 pack-years. Associations between smoking and the specific aberrations -5/5q-, -7/7q-, and +8 in AML and MDS were indicated but the estimates were imprecise.
U2 - 10.1016/j.leukres.2008.10.009
DO - 10.1016/j.leukres.2008.10.009
M3 - Article
SN - 1873-5835
VL - Nov 17
SP - 788
EP - 791
JO - Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
JF - Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
ER -
