Smoking modifies the associated increased risk of future cardiovascular disease by genetic variation on chromosome 9p21.

Viktor Hamrefors; Bo Hedblad; George Hindy; Gustav Smith; Peter Almgren; Gunnar Engström; Marketa Sjögren; Klas Gränsbo; Marju Orho-Melander; Olle Melander

doi:10.1371/journal.pone.0085893

Smoking modifies the associated increased risk of future cardiovascular disease by genetic variation on chromosome 9p21.

Viktor Hamrefors, Bo Hedblad, George Hindy, Gustav Smith, Peter Almgren, Gunnar Engström, Marketa Sjögren, Klas Gränsbo, Marju Orho-Melander, Olle Melander

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Abstract

Genetic predisposition for cardiovascular disease (CVD) is likely to be modified by environmental exposures. We tested if the associated risk of CVD and CVD-mortality by the single nucleotide polymorphism rs4977574 on chromosome 9p21 is modified by life-style factors.

Original language	English
Article number	e85893
Journal	PLoS ONE
Volume	9
Issue number	1
DOIs	https://doi.org/10.1371/journal.pone.0085893
Publication status	Published - 2014

Subject classification (UKÄ)

Endocrinology and Diabetes
Cardiac and Cardiovascular Systems

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10.1371/journal.pone.0085893

PLoS__Hamrefors_et_al

http://www.ncbi.nlm.nih.gov/pubmed/24465769?dopt=Abstract

Cite this

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title = "Smoking modifies the associated increased risk of future cardiovascular disease by genetic variation on chromosome 9p21.",

abstract = "Genetic predisposition for cardiovascular disease (CVD) is likely to be modified by environmental exposures. We tested if the associated risk of CVD and CVD-mortality by the single nucleotide polymorphism rs4977574 on chromosome 9p21 is modified by life-style factors.",

author = "Viktor Hamrefors and Bo Hedblad and George Hindy and Gustav Smith and Peter Almgren and Gunnar Engstr{\"o}m and Marketa Sj{\"o}gren and Klas Gr{\"a}nsbo and Marju Orho-Melander and Olle Melander",

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AU - Hamrefors, Viktor

AU - Hedblad, Bo

AU - Hindy, George

AU - Smith, Gustav

AU - Almgren, Peter

AU - Engström, Gunnar

AU - Sjögren, Marketa

AU - Gränsbo, Klas

AU - Orho-Melander, Marju

AU - Melander, Olle

PY - 2014

Y1 - 2014

N2 - Genetic predisposition for cardiovascular disease (CVD) is likely to be modified by environmental exposures. We tested if the associated risk of CVD and CVD-mortality by the single nucleotide polymorphism rs4977574 on chromosome 9p21 is modified by life-style factors.

AB - Genetic predisposition for cardiovascular disease (CVD) is likely to be modified by environmental exposures. We tested if the associated risk of CVD and CVD-mortality by the single nucleotide polymorphism rs4977574 on chromosome 9p21 is modified by life-style factors.

U2 - 10.1371/journal.pone.0085893

DO - 10.1371/journal.pone.0085893

M3 - Article

VL - 9

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 1

M1 - e85893

ER -

Smoking modifies the associated increased risk of future cardiovascular disease by genetic variation on chromosome 9p21.

Abstract

Subject classification (UKÄ)

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