Societal costs associated to chronic thromboembolic pulmonary hypertension: A study utilizing linked national registries

Barbro Kjellström, Hannes Runheim, Amélie Beaudet, Magnus Husberg, Bodil Ivarsson, Nadia Pillai, Lars Åke Levin, Lars Bernfort

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare but serious complication after a pulmonary embolism. Healthcare resource utilization (HCRU; hospitalization, outpatient visits, and drug utilization) as well as productivity loss (sick leave and disability pension) before and after the CTEPH diagnosis is sparsely studied. By linking several Swedish national databases, this study estimated the societal costs in a national CTEPH cohort (n = 369, diagnosed with CTEPH in 2008−2019) 5 years before and 5 years after diagnosis (index date) and compared to an age, sex, and geographically matched control group (n = 1845, 1:5 match). HCRU and productivity loss were estimated per patient per year. Patients were stratified as operated with pulmonary endarterectomy (PEA group) or not operated (non-PEA group). Direct and indirect societal costs were 2.1 times higher before, and 8.1 times higher after the index date for patients with CTEPH compared to the matched control groups. The higher costs were evident already several years preceding the index date. The main cost driver before the index date in both the PEA and the non-PEA groups was productivity loss. The productivity loss remained high for both groups in the 5-year period following the index date, but the main cost drivers were prescribed drugs and hospitalizations for patients that underwent PEA and prescribed drugs in the non-PEA group. In conclusion, CTEPH was associated with large societal costs related to healthcare consumption and productivity loss, both before and after diagnosis.

Original languageEnglish
Article numbere12254
JournalPulmonary Circulation
Volume13
Issue number2
DOIs
Publication statusPublished - 2023 Apr

Subject classification (UKÄ)

  • Family Medicine

Free keywords

  • burden of disease
  • burden of illness
  • mortality
  • national registry
  • pulmonary embolism

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