Solid-liquid interface method (SLIM): a new crystallization method for proteins

Erik Brostromer, Jie Nan, Lan-Fen Li, Xiao-Dong Su

Research output: Contribution to journalArticlepeer-review


Despite impressive advances in theories, methods and technologies, crystallization still remains a serious bottleneck in structural determination of macromolecules. Here we present a novel solid-liquid interface method (SLIM) for protein crystallization, based on the pre-adding and drying of a crystallization reagent, and thereafter the dispensing of a protein solution to the dried media to initiate crystallization from the solid-liquid interface. Not only quick and easy to perform, the method also allows for a less concentrated protein solution for setting up crystallization trials.

Original languageEnglish
Pages (from-to)634-8
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number4
Publication statusPublished - 2009 Sep 4


  • Crystallization
  • Proteins


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