Soluble Urokinase Plasminogen Activator Receptor is Associated With Inflammation in the Vulnerable Human Atherosclerotic Plaque.

Andreas Edsfeldt, Mihaela Nitulescu, Helena Grufman, Caitriona Grönberg, Ana Persson, Marie MN Nilsson, Margaretha Persson, Harry Björkbacka, Isabel Goncalves

Research output: Contribution to journalArticlepeer-review

Abstract

Recently, plasma soluble urokinase plasminogen activator receptor (suPAR) has gained interest as a marker of cardiovascular risk. suPAR is released through the cleavage of urokinase plasminogen activator receptor (uPAR), which is found in monocytes, activated T-lymphocytes and endothelial cells, all involved in atherosclerosis. suPAR levels have been well studied in plasma, but no studies have focused on suPAR in human atherosclerotic plaques. The aim of this study was to determine whether suPAR measured in the plaque is associated with symptomatic plaques and plaque inflammation.
Original languageEnglish
Pages (from-to)3305-3312
JournalStroke: a journal of cerebral circulation
Volume43
Issue number12
DOIs
Publication statusPublished - 2012

Subject classification (UKÄ)

  • Neurology

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