Spare respiratory capacity, oxidative stress and excitotoxicity

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108 Citations (SciVal)

Abstract

Chronic exposure to glutamate (glutamate excitotoxicity) exacerbates neuronal damage in the aftermath of stroke and is implicated in a variety of neurodegenerative disorders. mitochondria play a central role in the survival or death of the exposed neuron. calcium, oxidative stress and ATP insufficiency play closely interlocked roles that may be investigated with primary neuronal cultures.
Original languageEnglish
Pages (from-to)1385-1388
JournalBiochemical Society Transactions
Volume37
DOIs
Publication statusPublished - 2009

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Neuronal Survival (013212041)

Subject classification (UKÄ)

  • Biochemistry and Molecular Biology

Keywords

  • oxidative
  • mitochondrion
  • ischaemia
  • glutamate
  • ATP
  • excitotoxicity
  • stress

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