Abstract
Chronic exposure to glutamate (glutamate excitotoxicity) exacerbates neuronal damage in the aftermath of stroke and is implicated in a variety of neurodegenerative disorders. mitochondria play a central role in the survival or death of the exposed neuron. calcium, oxidative stress and ATP insufficiency play closely interlocked roles that may be investigated with primary neuronal cultures.
| Original language | English |
|---|---|
| Pages (from-to) | 1385-1388 |
| Journal | Biochemical Society Transactions |
| Volume | 37 |
| DOIs | |
| Publication status | Published - 2009 |
Bibliographical note
The information about affiliations in this record was updated in December 2015.The record was previously connected to the following departments: Neuronal Survival (013212041)
Subject classification (UKÄ)
- Biochemistry and Molecular Biology
Free keywords
- oxidative
- mitochondrion
- ischaemia
- glutamate
- ATP
- excitotoxicity
- stress