Stabilins are expressed in bone marrow sinusoidal endothelial cells and mediate scavenging and cell adhesive functions.

Hong Qian, Sophie Johansson, Peter McCourt, Bård Smedsrød, Marja Ekblom, Staffan Johansson

Research output: Contribution to journalArticlepeer-review

189 Downloads (Pure)

Abstract

Bone marrow sinusoidal endothelial cells have a specific function as a site of transmigration of hematopoietic stem and progenitor cells and mature blood cells between bone marrow and blood stream. However, the specific characteristics of bone marrow sinusoidal endothelial cells are still largely unclear. We here report that these cells express stabilin-1 and stabilin-2, which in liver sinusoidal endothelial cells have been identified as endocytic scavenger receptors for several ligands, including SPARC and hyaluronan. We show here that intravenously injected formaldehyde-treated serum albumin, advanced glycation end-products, and collagen I alpha-chains were taken up by bone marrow sinusoidal endothelial cells, showing that these cells have a scavenging function and thereby may modulate bone marrow vascular stem cell niches. Importantly, we show hyaluronan mediated adhesion of hematopoietic stem and progenitor cells to stabilin-2-transfected cells, suggesting that stabilin-2 contributes to adhesion and homing of circulating stem and progenitor cells to bone marrow.
Original languageEnglish
Pages (from-to)883-886
JournalBiochemical and Biophysical Research Communications
Volume390
DOIs
Publication statusPublished - 2009

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: The Vårdal Institute (016540000), Hematopoietic Stem Cell Laboratory (013022012)

Subject classification (UKÄ)

  • Biological Sciences

Fingerprint

Dive into the research topics of 'Stabilins are expressed in bone marrow sinusoidal endothelial cells and mediate scavenging and cell adhesive functions.'. Together they form a unique fingerprint.

Cite this