Stable Peptide of the Endogenous Opioid Enkephalin Precursor and Breast Cancer Risk.

Olle Melander; Marju Orho-Melander; Jonas Manjer; Thomas Svensson; Peter Almgren; Peter Nilsson; Gunnar Engström; Bo Hedblad; Signe Borgquist; Oliver Hartmann; Joachim Struck; Andreas Bergmann; Mattias Belting

doi:10.1200/JCO.2014.59.7682

Stable Peptide of the Endogenous Opioid Enkephalin Precursor and Breast Cancer Risk.

Olle Melander, Marju Orho-Melander, Jonas Manjer, Thomas Svensson, Peter Almgren, Peter Nilsson, Gunnar Engström, Bo Hedblad, Signe Borgquist, Oliver Hartmann, Joachim Struck, Andreas Bergmann, Mattias Belting

Research output: Contribution to journal › Article › peer-review

Abstract

In experimental studies, enkephalins (ENKs) and related opioids have been implicated as negative regulators of breast cancer development by enhancing immune-mediated tumoral defense as well as directly inhibiting cancer cells. We hypothesized that plasma levels of ENKs are predictive of the long-term breast cancer risk. Therefore, our objective was to measure pro-ENK A, a surrogate for mature ENK, and evaluate its predictive value for the development of breast cancer in a large population of middle-aged women and an independent study population.

Original language	English
Pages (from-to)	2632-U81
Journal	Journal of Clinical Oncology
Volume	33
Issue number	24
DOIs	https://doi.org/10.1200/JCO.2014.59.7682
Publication status	Published - 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Subject classification (UKÄ)

Cancer and Oncology

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10.1200/JCO.2014.59.7682

http://www.ncbi.nlm.nih.gov/pubmed/26169618?dopt=Abstract

Cite this

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title = "Stable Peptide of the Endogenous Opioid Enkephalin Precursor and Breast Cancer Risk.",

abstract = "In experimental studies, enkephalins (ENKs) and related opioids have been implicated as negative regulators of breast cancer development by enhancing immune-mediated tumoral defense as well as directly inhibiting cancer cells. We hypothesized that plasma levels of ENKs are predictive of the long-term breast cancer risk. Therefore, our objective was to measure pro-ENK A, a surrogate for mature ENK, and evaluate its predictive value for the development of breast cancer in a large population of middle-aged women and an independent study population.",

author = "Olle Melander and Marju Orho-Melander and Jonas Manjer and Thomas Svensson and Peter Almgren and Peter Nilsson and Gunnar Engstr{\"o}m and Bo Hedblad and Signe Borgquist and Oliver Hartmann and Joachim Struck and Andreas Bergmann and Mattias Belting",

year = "2015",

doi = "10.1200/JCO.2014.59.7682",

language = "English",

volume = "33",

pages = "2632--U81",

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publisher = "Lippincott Williams \& Wilkins",

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TY - JOUR

T1 - Stable Peptide of the Endogenous Opioid Enkephalin Precursor and Breast Cancer Risk.

AU - Melander, Olle

AU - Orho-Melander, Marju

AU - Manjer, Jonas

AU - Svensson, Thomas

AU - Almgren, Peter

AU - Nilsson, Peter

AU - Engström, Gunnar

AU - Hedblad, Bo

AU - Borgquist, Signe

AU - Hartmann, Oliver

AU - Struck, Joachim

AU - Bergmann, Andreas

AU - Belting, Mattias

PY - 2015

Y1 - 2015

N2 - In experimental studies, enkephalins (ENKs) and related opioids have been implicated as negative regulators of breast cancer development by enhancing immune-mediated tumoral defense as well as directly inhibiting cancer cells. We hypothesized that plasma levels of ENKs are predictive of the long-term breast cancer risk. Therefore, our objective was to measure pro-ENK A, a surrogate for mature ENK, and evaluate its predictive value for the development of breast cancer in a large population of middle-aged women and an independent study population.

AB - In experimental studies, enkephalins (ENKs) and related opioids have been implicated as negative regulators of breast cancer development by enhancing immune-mediated tumoral defense as well as directly inhibiting cancer cells. We hypothesized that plasma levels of ENKs are predictive of the long-term breast cancer risk. Therefore, our objective was to measure pro-ENK A, a surrogate for mature ENK, and evaluate its predictive value for the development of breast cancer in a large population of middle-aged women and an independent study population.

UR - https://www.scopus.com/pages/publications/84940521359

U2 - 10.1200/JCO.2014.59.7682

DO - 10.1200/JCO.2014.59.7682

M3 - Article

C2 - 26169618

SN - 1527-7755

VL - 33

SP - 2632-U81

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

IS - 24

ER -

Stable Peptide of the Endogenous Opioid Enkephalin Precursor and Breast Cancer Risk.

Abstract

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Subject classification (UKÄ)

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