Statin-induced anti-proliferative effects via cyclin D1 and p27 in a window-of-opportunity breast cancer trial.

Maria Feldt; Olöf Bjarnadottir; Siker Kimbung; Karin Jirström; Pär-Ola Bendahl; Srinivas Veerla; Dorthe Grabau; Ingrid Hedenfalk; Signe Borgquist

doi:10.1186/s12967-015-0486-0

Statin-induced anti-proliferative effects via cyclin D1 and p27 in a window-of-opportunity breast cancer trial.

Maria Feldt, Olöf Bjarnadottir, Siker Kimbung, Karin Jirström, Pär-Ola Bendahl, Srinivas Veerla, Dorthe Grabau, Ingrid Hedenfalk, Signe Borgquist

Research output: Contribution to journal › Article › peer-review

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Abstract

Cholesterol lowering statins have been demonstrated to exert anti-tumoral effects on breast cancer by decreasing proliferation as measured by Ki67. The biological mechanisms behind the anti-proliferative effects remain elusive. The aim of this study was to investigate potential statin-induced effects on the central cell cycle regulators cyclin D1 and p27.

Original language	English
Journal	Journal of Translational Medicine
Volume	13
Issue number	133
DOIs	https://doi.org/10.1186/s12967-015-0486-0
Publication status	Published - 2015

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Pathology, (Lund) (013030000), Oncology, MV (013035000)

Subject classification (UKÄ)

Cancer and Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/s12967-015-0486-0

BMC_Feldt_et_al

http://www.ncbi.nlm.nih.gov/pubmed/25925673?dopt=Abstract

2 Doctoral Thesis (compilation)

Targeting the role of statins in breast cancer – through translationally edged clinical trials
Feldt, M., 2021, Lund: Lund University, Faculty of Medicine. 101 p.
Research output: Thesis › Doctoral Thesis (compilation)
Statins, HMGCR and Breast Cancer
Bjarnadottir, O., 2017, Lund: Lund University: Faculty of Medicine. 97 p.
Research output: Thesis › Doctoral Thesis (compilation)

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title = "Statin-induced anti-proliferative effects via cyclin D1 and p27 in a window-of-opportunity breast cancer trial.",

abstract = "Cholesterol lowering statins have been demonstrated to exert anti-tumoral effects on breast cancer by decreasing proliferation as measured by Ki67. The biological mechanisms behind the anti-proliferative effects remain elusive. The aim of this study was to investigate potential statin-induced effects on the central cell cycle regulators cyclin D1 and p27.",

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note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Oncology, MV (013035000)",

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doi = "10.1186/s12967-015-0486-0",

language = "English",

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TY - JOUR

T1 - Statin-induced anti-proliferative effects via cyclin D1 and p27 in a window-of-opportunity breast cancer trial.

AU - Feldt, Maria

AU - Bjarnadottir, Olöf

AU - Kimbung, Siker

AU - Jirström, Karin

AU - Bendahl, Pär-Ola

AU - Veerla, Srinivas

AU - Grabau, Dorthe

AU - Hedenfalk, Ingrid

AU - Borgquist, Signe

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Oncology, MV (013035000)

PY - 2015

Y1 - 2015

N2 - Cholesterol lowering statins have been demonstrated to exert anti-tumoral effects on breast cancer by decreasing proliferation as measured by Ki67. The biological mechanisms behind the anti-proliferative effects remain elusive. The aim of this study was to investigate potential statin-induced effects on the central cell cycle regulators cyclin D1 and p27.

AB - Cholesterol lowering statins have been demonstrated to exert anti-tumoral effects on breast cancer by decreasing proliferation as measured by Ki67. The biological mechanisms behind the anti-proliferative effects remain elusive. The aim of this study was to investigate potential statin-induced effects on the central cell cycle regulators cyclin D1 and p27.

U2 - 10.1186/s12967-015-0486-0

DO - 10.1186/s12967-015-0486-0

M3 - Article

C2 - 25925673

SN - 1479-5876

VL - 13

JO - Journal of Translational Medicine

JF - Journal of Translational Medicine

IS - 133

ER -

Statin-induced anti-proliferative effects via cyclin D1 and p27 in a window-of-opportunity breast cancer trial.

Abstract

Bibliographical note

Subject classification (UKÄ)

UN SDGs

Access to Document

Fingerprint

Research output

Targeting the role of statins in breast cancer – through translationally edged clinical trials

Statins, HMGCR and Breast Cancer

Cite this