Strategies for studying bacterial adhesion in Vivo

Hakon Leffler, William Agace, Spencer Hedges, Ragnar Lindstedt, Majlis Svensson, Catharina Svanborg

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review


The ultimate goal of studies on microbial adhesion is to understand what molecular interactions between the host and microbe occur in vivo and the impact of these interactions on disease processes. With this goal in mind, the problem can be approached at four levels. At the biochemical level, the host receptors at the relevant colonization site are identified; at the cell biology level, consequences of bacterial binding to host epithelial cells are studied in cell culture; at the physiological level, the consequences of bacterial binding are studied in experimental animals or humans; and at the population level, the consequences of receptor binding for colonization are studied by epidemiological methods. This chapter provides an example of studies at each level and discusses the implications for what might occur in vivo.

Original languageEnglish
Title of host publicationAdhesion of Microbial Pathogens
EditorsRon J. Doyle, Itzhak Ofek
Publication statusPublished - 1995

Publication series

NameMethods in Enzymology
PublisherAcademic Press
ISSN (Print)0076-6879

Subject classification (UKÄ)

  • Cell and Molecular Biology


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