Stressin’ and slicin’: stress-induced tRNA fragmentation codon-adapts translation to repress cell growth

Nicola Guzzi, Cristian Bellodi

Research output: Contribution to journalDebate/Note/Editorialpeer-review

1 Citation (SciVal)

Abstract

Transfer RNAs (tRNAs) are central adaptors that decode genetic information during translation and have been long considered static cellular components. However, whether dynamic changes in tRNAs and tRNA-derived fragments actively contribute to gene regulation remains debated. In this issue, Huh et al (2020) highlight tyrosine tRNAGUA fragmentation at the nexus of an evolutionarily conserved adaptive codon-based stress response that fine-tunes translation to restrain growth in human cells.

Original languageEnglish
JournalEMBO Journal
Volume40
Issue number2
Early online date2020 Dec 21
DOIs
Publication statusPublished - 2021

Subject classification (UKÄ)

  • Biochemistry and Molecular Biology

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