Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma.

Michael Dictor; Sara Ek; Maria Sundberg; Janina Warenholt; Czabafy György; Sandra Sernbo; Elin Gustavsson; Waleed Abu Al-Soud; Torkel Wadström; Carl Borrebaeck

doi:10.3324/haematol.2009.008474

Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma.

Michael Dictor, Sara Ek, Maria Sundberg, Janina Warenholt, Czabafy György, Sandra Sernbo, Elin Gustavsson, Waleed Abu Al-Soud, Torkel Wadström, Carl Borrebaeck

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Abstract

BACKGROUND: We surveyed lymphomas to determine the range of expression of the mantle cell lymphoma-associated SOX11 transcription factor and its relation to cyclin D1. DESIGN AND METHODS: On hundred and seventy-two specimens were immunostained for the SOX11 N and C termini. Cyclin D1 was detected by immunohistochemistry and quantitative reverse transcriptase polymerase chain reaction; in situ hybridization for t(11;14) was applied when needed. RESULTS: Nuclear SOX11 was strongly expressed in most B and T-lymphoblastic leukemia/lymphomas and half of childhood Burkitt's lymphomas, but only weakly expressed in some hairy cell leukemias. Chronic lymphocytic leukemia/lymphoma, marginal zone, follicular and diffuse large B-cell lymphomas were negative for SOX11, as were all cases of intermediate Burkitt's lymphomas/diffuse large B-cell lymphoma, myeloma, Hodgkin's lymphomas and mature T-cell and NK/T-cell lymphomas. CONCLUSIONS: In addition to mantle cell lymphoma, SOX11 is strongly expressed only in lymphoblastic malignancies and Burkitt's lymphomas. Its expression is independent of cyclin D1 (except for weak expression in hairy cell leukemias) and unlikely to be due to translocations in lymphoid neoplasia.

Original language	English
Pages (from-to)	1563-1568
Journal	Haematologica
Volume	94
Issue number	11
DOIs	https://doi.org/10.3324/haematol.2009.008474
Publication status	Published - 2009

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Division of Medical Microbiology (013250400), Department of Immunotechnology (011029300), Pathology, (Lund) (013030000)

Subject classification (UKÄ)

Hematology

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10.3324/haematol.2009.008474

DictorHaematologica

http://www.ncbi.nlm.nih.gov/pubmed/19880779?dopt=Abstract

1 Doctoral Thesis (compilation)

SOX11 as a Cancer Biomarker - Expression and Regulatory Studies in B-cell Lymphomas and Ovarian Cancer
Gustavsson, E., 2010
Research output: Thesis › Doctoral Thesis (compilation)

Cite this

@article{0935d020aa634106b33149cfb0e1179e,

title = "Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma.",

abstract = "BACKGROUND: We surveyed lymphomas to determine the range of expression of the mantle cell lymphoma-associated SOX11 transcription factor and its relation to cyclin D1. DESIGN AND METHODS: On hundred and seventy-two specimens were immunostained for the SOX11 N and C termini. Cyclin D1 was detected by immunohistochemistry and quantitative reverse transcriptase polymerase chain reaction; in situ hybridization for t(11;14) was applied when needed. RESULTS: Nuclear SOX11 was strongly expressed in most B and T-lymphoblastic leukemia/lymphomas and half of childhood Burkitt's lymphomas, but only weakly expressed in some hairy cell leukemias. Chronic lymphocytic leukemia/lymphoma, marginal zone, follicular and diffuse large B-cell lymphomas were negative for SOX11, as were all cases of intermediate Burkitt's lymphomas/diffuse large B-cell lymphoma, myeloma, Hodgkin's lymphomas and mature T-cell and NK/T-cell lymphomas. CONCLUSIONS: In addition to mantle cell lymphoma, SOX11 is strongly expressed only in lymphoblastic malignancies and Burkitt's lymphomas. Its expression is independent of cyclin D1 (except for weak expression in hairy cell leukemias) and unlikely to be due to translocations in lymphoid neoplasia.",

author = "Michael Dictor and Sara Ek and Maria Sundberg and Janina Warenholt and Czabafy Gy{\"o}rgy and Sandra Sernbo and Elin Gustavsson and {Abu Al-Soud}, Waleed and Torkel Wadstr{\"o}m and Carl Borrebaeck",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Medical Microbiology (013250400), Department of Immunotechnology (011029300), Pathology, (Lund) (013030000)",

year = "2009",

doi = "10.3324/haematol.2009.008474",

language = "English",

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pages = "1563--1568",

journal = "Haematologica",

issn = "1592-8721",

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Dictor, M, Ek, S, Sundberg, M, Warenholt, J, György, C, Sernbo, S, Gustavsson, E, Abu Al-Soud, W, Wadström, T & Borrebaeck, C 2009, 'Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma.', Haematologica, vol. 94, no. 11, pp. 1563-1568. https://doi.org/10.3324/haematol.2009.008474

TY - JOUR

T1 - Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma.

AU - Dictor, Michael

AU - Ek, Sara

AU - Sundberg, Maria

AU - Warenholt, Janina

AU - György, Czabafy

AU - Sernbo, Sandra

AU - Gustavsson, Elin

AU - Abu Al-Soud, Waleed

AU - Wadström, Torkel

AU - Borrebaeck, Carl

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Medical Microbiology (013250400), Department of Immunotechnology (011029300), Pathology, (Lund) (013030000)

PY - 2009

Y1 - 2009

N2 - BACKGROUND: We surveyed lymphomas to determine the range of expression of the mantle cell lymphoma-associated SOX11 transcription factor and its relation to cyclin D1. DESIGN AND METHODS: On hundred and seventy-two specimens were immunostained for the SOX11 N and C termini. Cyclin D1 was detected by immunohistochemistry and quantitative reverse transcriptase polymerase chain reaction; in situ hybridization for t(11;14) was applied when needed. RESULTS: Nuclear SOX11 was strongly expressed in most B and T-lymphoblastic leukemia/lymphomas and half of childhood Burkitt's lymphomas, but only weakly expressed in some hairy cell leukemias. Chronic lymphocytic leukemia/lymphoma, marginal zone, follicular and diffuse large B-cell lymphomas were negative for SOX11, as were all cases of intermediate Burkitt's lymphomas/diffuse large B-cell lymphoma, myeloma, Hodgkin's lymphomas and mature T-cell and NK/T-cell lymphomas. CONCLUSIONS: In addition to mantle cell lymphoma, SOX11 is strongly expressed only in lymphoblastic malignancies and Burkitt's lymphomas. Its expression is independent of cyclin D1 (except for weak expression in hairy cell leukemias) and unlikely to be due to translocations in lymphoid neoplasia.

AB - BACKGROUND: We surveyed lymphomas to determine the range of expression of the mantle cell lymphoma-associated SOX11 transcription factor and its relation to cyclin D1. DESIGN AND METHODS: On hundred and seventy-two specimens were immunostained for the SOX11 N and C termini. Cyclin D1 was detected by immunohistochemistry and quantitative reverse transcriptase polymerase chain reaction; in situ hybridization for t(11;14) was applied when needed. RESULTS: Nuclear SOX11 was strongly expressed in most B and T-lymphoblastic leukemia/lymphomas and half of childhood Burkitt's lymphomas, but only weakly expressed in some hairy cell leukemias. Chronic lymphocytic leukemia/lymphoma, marginal zone, follicular and diffuse large B-cell lymphomas were negative for SOX11, as were all cases of intermediate Burkitt's lymphomas/diffuse large B-cell lymphoma, myeloma, Hodgkin's lymphomas and mature T-cell and NK/T-cell lymphomas. CONCLUSIONS: In addition to mantle cell lymphoma, SOX11 is strongly expressed only in lymphoblastic malignancies and Burkitt's lymphomas. Its expression is independent of cyclin D1 (except for weak expression in hairy cell leukemias) and unlikely to be due to translocations in lymphoid neoplasia.

U2 - 10.3324/haematol.2009.008474

DO - 10.3324/haematol.2009.008474

M3 - Article

C2 - 19880779

SN - 1592-8721

VL - 94

SP - 1563

EP - 1568

JO - Haematologica

JF - Haematologica

IS - 11

ER -

Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma.

Abstract

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Research output

SOX11 as a Cancer Biomarker - Expression and Regulatory Studies in B-cell Lymphomas and Ovarian Cancer

Cite this