Abstract
AQP7 is an important glycerol channel in human adipocytes, and its dysfunction is linked to metabolic disorders. The high-resolution X-ray structures of AQP7 unravels the molecular details of how glycerol travels through the channel and provide a structural basis for development of small-molecule drugs for targeting AQP7.
Original language | English |
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Pages (from-to) | 215-222.e3 |
Journal | Structure |
Volume | 28 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2020 Feb 4 |
Subject classification (UKÄ)
- Structural Biology
Free keywords
- adipocyte
- AQP7
- aquaglyceroporin
- aquaporin 7
- atomistic MD simulations
- glycerol channel
- water
- X-ray structure