Structural Basis for Glycerol Efflux and Selectivity of Human Aquaporin 7

Sofia W. de Maré, Raminta Venskutonytė, Sandra Eltschkner, Bert L. de Groot, Karin Lindkvist-Petersson

Research output: Contribution to journalArticlepeer-review

Abstract

AQP7 is an important glycerol channel in human adipocytes, and its dysfunction is linked to metabolic disorders. The high-resolution X-ray structures of AQP7 unravels the molecular details of how glycerol travels through the channel and provide a structural basis for development of small-molecule drugs for targeting AQP7.

Original languageEnglish
Pages (from-to)215-222.e3
JournalStructure
Volume28
Issue number2
DOIs
Publication statusPublished - 2020 Feb 4

Subject classification (UKÄ)

  • Structural Biology

Free keywords

  • adipocyte
  • AQP7
  • aquaglyceroporin
  • aquaporin 7
  • atomistic MD simulations
  • glycerol channel
  • water
  • X-ray structure

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