Structural changes in the developing retina maintained in vitro.

Kjell Johansson, Berndt Ehinger

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The present study examined the emergence of structural remodeling in explanted neonatal rat retina. Immunohistochemical analysis demonstrated signs of glial and neuronal remodeling after I I days in vitro and included the activation of Muller cells, the formation of ectopic neuropil areas and sprouting of photoreceptor terminals. We also observed that cholinergic and GABA-ergic amacrine cells displayed signs of disorganized laminations. These results demonstrate that retinal culturing initiates structural changes that show morphological similarities to glial and neuronal remodeling identified in retinitis pigmentosa retinas and experimentally detached retinas.
Original languageEnglish
Pages (from-to)3235-3243
JournalVision Research
Issue number25-26
Publication statusPublished - 2005

Subject classification (UKÄ)

  • Ophthalmology


  • Muller cells
  • photoreceptor sprouting
  • in vitro
  • retina
  • remodeling


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