Structural studies of cysteine proteases and their inhibitors

Zbigniew Grzonka, Elzbieta Jankowska, Franciszek Kasprzykowski, Regina Kasprzykowska, Leszek Lankiewicz, Wieslaw Wiczk, Ewa Wieczerzak, Jerzy Ciarkowski, Piotr Drabik, Robert Janowski, Maciej Kozak, Mariusz Jaskolski, Anders Grubb

Research output: Contribution to journalReview articlepeer-review


Cysteine proteases (CPs) are responsible for many biochemical processes occurring in living organisms and they have been implicated in the development and progression of several diseases that involve abnormal protein turnover. The activity of CPs is regulated among others by their specific inhibitors: cystatins. The main aim of this review is to discuss the structure-activity relationships of cysteine proteases and cystatins, as well as of some synthetic inhibitors of cysteine proteases structurally based on the binding fragments of cystatins.
Original languageEnglish
Pages (from-to)1-20
JournalActa Biochimica Polonica
Issue number1
Publication statusPublished - 2001

Subject classification (UKÄ)

  • Medicinal Chemistry
  • Pharmacology and Toxicology

Free keywords

  • structure-activity relationship
  • synthetic inhibitors
  • cystatins
  • cysteine proteases


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