Structural studies of cysteine proteases and their inhibitors

Zbigniew Grzonka; Elzbieta Jankowska; Franciszek Kasprzykowski; Regina Kasprzykowska; Leszek Lankiewicz; Wieslaw Wiczk; Ewa Wieczerzak; Jerzy Ciarkowski; Piotr Drabik; Robert Janowski; Maciej Kozak; Mariusz Jaskolski; Anders Grubb

Structural studies of cysteine proteases and their inhibitors

Zbigniew Grzonka, Elzbieta Jankowska, Franciszek Kasprzykowski, Regina Kasprzykowska, Leszek Lankiewicz, Wieslaw Wiczk, Ewa Wieczerzak, Jerzy Ciarkowski, Piotr Drabik, Robert Janowski, Maciej Kozak, Mariusz Jaskolski, Anders Grubb

Division of Clinical Chemistry and Pharmacology

Research output: Contribution to journal › Review article › peer-review

Abstract

Cysteine proteases (CPs) are responsible for many biochemical processes occurring in living organisms and they have been implicated in the development and progression of several diseases that involve abnormal protein turnover. The activity of CPs is regulated among others by their specific inhibitors: cystatins. The main aim of this review is to discuss the structure-activity relationships of cysteine proteases and cystatins, as well as of some synthetic inhibitors of cysteine proteases structurally based on the binding fragments of cystatins.

Original language	English
Pages (from-to)	1-20
Journal	Acta Biochimica Polonica
Volume	48
Issue number	1
Publication status	Published - 2001

Subject classification (UKÄ)

Medicinal Chemistry
Pharmacology and Toxicology

Free keywords

structure-activity relationship
synthetic inhibitors
cystatins
cysteine proteases

Cite this

@article{c2f3df10c7524141874c959b2156c0d3,

title = "Structural studies of cysteine proteases and their inhibitors",

abstract = "Cysteine proteases (CPs) are responsible for many biochemical processes occurring in living organisms and they have been implicated in the development and progression of several diseases that involve abnormal protein turnover. The activity of CPs is regulated among others by their specific inhibitors: cystatins. The main aim of this review is to discuss the structure-activity relationships of cysteine proteases and cystatins, as well as of some synthetic inhibitors of cysteine proteases structurally based on the binding fragments of cystatins.",

keywords = "structure-activity relationship, synthetic inhibitors, cystatins, cysteine proteases",

author = "Zbigniew Grzonka and Elzbieta Jankowska and Franciszek Kasprzykowski and Regina Kasprzykowska and Leszek Lankiewicz and Wieslaw Wiczk and Ewa Wieczerzak and Jerzy Ciarkowski and Piotr Drabik and Robert Janowski and Maciej Kozak and Mariusz Jaskolski and Anders Grubb",

year = "2001",

language = "English",

volume = "48",

pages = "1--20",

journal = "Acta Biochimica Polonica",

issn = "0001-527X",

publisher = "Panstwowe Wydawnictwo Naukowe",

number = "1",

}

TY - JOUR

T1 - Structural studies of cysteine proteases and their inhibitors

AU - Grzonka, Zbigniew

AU - Jankowska, Elzbieta

AU - Kasprzykowski, Franciszek

AU - Kasprzykowska, Regina

AU - Lankiewicz, Leszek

AU - Wiczk, Wieslaw

AU - Wieczerzak, Ewa

AU - Ciarkowski, Jerzy

AU - Drabik, Piotr

AU - Janowski, Robert

AU - Kozak, Maciej

AU - Jaskolski, Mariusz

AU - Grubb, Anders

PY - 2001

Y1 - 2001

N2 - Cysteine proteases (CPs) are responsible for many biochemical processes occurring in living organisms and they have been implicated in the development and progression of several diseases that involve abnormal protein turnover. The activity of CPs is regulated among others by their specific inhibitors: cystatins. The main aim of this review is to discuss the structure-activity relationships of cysteine proteases and cystatins, as well as of some synthetic inhibitors of cysteine proteases structurally based on the binding fragments of cystatins.

AB - Cysteine proteases (CPs) are responsible for many biochemical processes occurring in living organisms and they have been implicated in the development and progression of several diseases that involve abnormal protein turnover. The activity of CPs is regulated among others by their specific inhibitors: cystatins. The main aim of this review is to discuss the structure-activity relationships of cysteine proteases and cystatins, as well as of some synthetic inhibitors of cysteine proteases structurally based on the binding fragments of cystatins.

KW - structure-activity relationship

KW - synthetic inhibitors

KW - cystatins

KW - cysteine proteases

M3 - Review article

SN - 0001-527X

VL - 48

SP - 1

EP - 20

JO - Acta Biochimica Polonica

JF - Acta Biochimica Polonica

IS - 1

ER -

Structural studies of cysteine proteases and their inhibitors

Abstract

Subject classification (UKÄ)

Free keywords

Fingerprint

Cite this