Studies of different secondary metabolites: Natural products from the mevalonate pathway

Research output: ThesisDoctoral Thesis (compilation)

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Abstract

Natural products, also called secondary metabolites, are small molecules that are not involved in main life processes. These can be produced by any living organism and play important roles as chemical weapons, protecting the organism from the competitive environment.
Due to their bioactivity, natural products present in medicinal plants, mushrooms (and other organisms such as bacteria and algae) have been the source of medicine and the inspiration of modern dug discovery since they are characterized by an enormous scaffold diversity and structural complexity.
In the search of new natural products, this thesis comprises the study of natural products from two fungal species, Aleurodiscus sp. and Galiella Rufa.
From Aleurodiscus sp., 8 molecules in total were isolated, belonging to the benzofuran, chromane and chromene-type compounds.
From G. rufa no novel molecules were isolated since its chemistry is well known, however, this thesis comprises the use of its enzymatic potential to biotransform synthetic analogues of desoxygaliellalactone into galiellalactone and galiellalactam analogues.
Finally, from the medicinal plant Trichilia adolfi, nine novel limonoids-type natural products were isolated and evaluated as anti-parasitic agents.
Original languageEnglish
QualificationDoctor
Supervisors/Advisors
  • Sterner, Olov, Supervisor
  • Manner, Sophie, Supervisor
  • Ellervik, Ulf, Supervisor
Award date2021 Aug 26
Publisher
Print ISBNs978-91-7895-935-8
Electronic ISBNs978-91-7895-936-5
Publication statusPublished - 2021 Jun 4

Bibliographical note

Defence details
Date: 2021-08-26
Time: 14:00
Place: Kemicentrum Sal C Join via zoom: https://lu-se.zoom.us/j/69776660302?pwd=Zzg2bnVqbTliUkFpZ1dsdFp6WlJGdz09
External reviewer(s)
Name: Peña Rodríguez, Luis Manuel
Title: Doctor
Affiliation: Centro de Investigación Científica de Yucatán, Mérida, Yucatán, México
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Subject classification (UKÄ)

  • Organic Chemistry

Keywords

  • Natural products
  • fungi
  • Galiellalactone
  • Galiella rufa
  • Trichilia adolfi
  • benzofuran

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