@inproceedings{8e49a584439e427bb550edb5339c914c,
title = "Subarachnoid hemorrhage induces upregulation of vascular receptors and reduction in rCBF via an ERKI/2 mechanism",
abstract = "Previous studies have shown that endothelin type B (ETB) and 5-hydroxytryptamine type IB (5-HTIB) receptors are upregulated following subarachnoid hemorrhage (SAH). The purpose of the present study was to test whether extracellular signal-regulated kinase (ERKI/2) inhibition could alter the degree of SAH induced receptor upregulation in addition to prevent the cerebral blood flow (CBF) reduction. The ERKI/2 inhibitor SB386023-b was injected intra cisternally in conjunction with and after the induced SAH in rats. Two days after SAH cerebral arteries were harvested and the contractile response to endothelin-1 (ET-I) and 5-carboxamidotryptamine (5-CT) were investigated with a myograph. The contractile responses to ET-I and 5-CT were increased after SAH compared to sham. Administration of SB-386023-b prevented the upregulated contraction elicited by application of ET-I and 5-CT in cerebral arteries. Regional CBF evaluated by an autoradiographic technique, revealed a reduced CBF by 50% after SAH this was prevented by treatment with SB-386023-b. The results indicate that an ERKI/2 mechanism is involved in cerebral vasospasm and ischemia associated with SAH.",
keywords = "signal-regulated kinase (ERKI/2), extracellular, cerebral blood flow (CBF), cerebral ischemia, subarachnoid hemorrhage (SAH)",
author = "Saema Ansar and {Lundager Hansen}, Jakob and Lars Edvinsson",
year = "2008",
doi = "10.1007/978-3-211-75718-5_12",
language = "English",
isbn = "978-3-211-75717-8",
volume = "104",
publisher = "Springer",
pages = "65--67",
booktitle = "Cerebral Vasospasm: New Strategies in Research and Treatment",
address = "Germany",
note = "9th International Conference on Cerebral Vasospasm ; Conference date: 27-06-2006 Through 30-06-2006",
}