TY - JOUR
T1 - Subtypes of fruit and vegetables, variety in consumption and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition.
AU - Leenders, Max
AU - Siersema, Peter D
AU - Overvad, Kim
AU - Tjønneland, Anne
AU - Olsen, Anja
AU - Boutron-Ruault, Marie-Christine
AU - Bastide, Nadia
AU - Fagherazzi, Guy
AU - Katzke, Verena
AU - Kühn, Tilman
AU - Boeing, Heiner
AU - Aleksandrova, Krasimira
AU - Trichopoulou, Antonia
AU - Lagiou, Pagona
AU - Klinaki, Eleni
AU - Masala, Giovanna
AU - Grioni, Sara
AU - De Magistris, Maria Santucci
AU - Tumino, Rosario
AU - Ricceri, Fulvio
AU - Peeters, Petra H M
AU - Lund, Eiliv
AU - Skeie, Guri
AU - Weiderpass, Elisabete
AU - Quirós, J Ramón
AU - Agudo, Antonio
AU - Sánchez, María-José
AU - Dorronsoro, Miren
AU - Navarro, Carmen
AU - Ardanaz, Eva
AU - Ohlsson, Bodil
AU - Jirström, Karin
AU - Van Guelpen, Bethany
AU - Wennberg, Maria
AU - Khaw, Kay-Tee
AU - Wareham, Nick
AU - Key, Timothy J
AU - Romieu, Isabelle
AU - Huybrechts, Inge
AU - Cross, Amanda J
AU - Murphy, Neil
AU - Riboli, Elio
AU - Bueno-de-Mesquita, H Bas
N1 - The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Pathology, (Lund) (013030000), Faculty of Medicine (000022000), Internal Medicine Research Unit (013242520)
PY - 2015
Y1 - 2015
N2 - Previously, a lower risk of colorectal cancer was observed with fruit and vegetable consumption in the European Prospective Investigation into Cancer and Nutrition within a follow-up period of nine years which was not fully supported by a recent meta-analysis. Therefore, we were interested in the relation with extended follow-up, also focusing on single subtypes and variety of intake of fruit and vegetables. Fruit and vegetable consumption was assessed at baseline. After an average of thirteen years of follow-up, 3,370 participants were diagnosed with colon or rectal cancer. Diet diversity scores were constructed to quantify variety in fruit and vegetable consumption. A lower risk of colon cancer was observed with higher self-reported consumption of fruit and vegetable combined (HR Q4 vs. Q1 0.87, 95%CI 0.75-1.01, P for trend 0.02), but no consistent association was observed for separate consumption of fruits and vegetables. No associations with risk of rectal cancer were observed. The few observed associations for some fruit and vegetable subtypes with colon cancer risk may have been due to chance. Variety in consumption of fruits and vegetables was not associated with a lower risk of colon or rectal cancer. Although a lower risk of colon cancer is suggested with high consumption of fruit and vegetables, this study does not support a clear inverse association between fruit and vegetable consumption and colon or rectal cancer beyond a follow-up of more than ten years. Attenuation of the risk estimates from dietary changes over time cannot be excluded, but seems unlikely. This article is protected by copyright. All rights reserved.
AB - Previously, a lower risk of colorectal cancer was observed with fruit and vegetable consumption in the European Prospective Investigation into Cancer and Nutrition within a follow-up period of nine years which was not fully supported by a recent meta-analysis. Therefore, we were interested in the relation with extended follow-up, also focusing on single subtypes and variety of intake of fruit and vegetables. Fruit and vegetable consumption was assessed at baseline. After an average of thirteen years of follow-up, 3,370 participants were diagnosed with colon or rectal cancer. Diet diversity scores were constructed to quantify variety in fruit and vegetable consumption. A lower risk of colon cancer was observed with higher self-reported consumption of fruit and vegetable combined (HR Q4 vs. Q1 0.87, 95%CI 0.75-1.01, P for trend 0.02), but no consistent association was observed for separate consumption of fruits and vegetables. No associations with risk of rectal cancer were observed. The few observed associations for some fruit and vegetable subtypes with colon cancer risk may have been due to chance. Variety in consumption of fruits and vegetables was not associated with a lower risk of colon or rectal cancer. Although a lower risk of colon cancer is suggested with high consumption of fruit and vegetables, this study does not support a clear inverse association between fruit and vegetable consumption and colon or rectal cancer beyond a follow-up of more than ten years. Attenuation of the risk estimates from dietary changes over time cannot be excluded, but seems unlikely. This article is protected by copyright. All rights reserved.
U2 - 10.1002/ijc.29640
DO - 10.1002/ijc.29640
M3 - Article
C2 - 26077137
SN - 0020-7136
VL - 137
SP - 2705
EP - 2714
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 11
ER -