Sudden cardiac death in synucleinopathies

Keivan Javanshiri, Tove Drakenberg, Mattias Haglund, Elisabet Englund

Research output: Contribution to journalArticlepeer-review


The purpose of this study was to investigate the cause of death in subjects with α-synucleinopathies (ASs) and the confirmed presence of cardiac α-synuclein (α-syn), compared to non-AS disorders in a neuropathologically confirmed cohort. In total, 78 neuropathologically confirmed AS cases positive for cardiac α-syn were included in the study. Individuals with other neurocognitive diseases, having no α-syn in the brainstem or above, nor in cardiac nerves, served as controls (n = 53). Data regarding the cause of death, cardiac α-syn, pathological cardiac findings, and cardio- and cerebrovascular disease were assembled from autopsy reports and medical records. In the AS group, there was a significantly higher prevalence of sudden cardiac death ([SCD]; n = 40, 51.3%) compared to the control group (n = 12, 22.6%, p 
Original languageEnglish
Pages (from-to)242-249
JournalJournal of Neuropathology and Experimental Neurology
Issue number3
Early online date2023
Publication statusPublished - 2023

Subject classification (UKÄ)

  • Cardiac and Cardiovascular Systems


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