Suicidal patients are deficient in vitamin D, associated with a pro-inflammatory status in the blood.

Cécile Grudet; Johan Malm; Åsa Westrin; Lena Brundin

doi:10.1016/j.psyneuen.2014.08.016

Suicidal patients are deficient in vitamin D, associated with a pro-inflammatory status in the blood.

Cécile Grudet, Johan Malm, Åsa Westrin, Lena Brundin

Research output: Contribution to journal › Article › peer-review

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Abstract

Low levels of vitamin D may play a role in psychiatric disorders, as cross-sectional studies show an association between vitamin D deficiency and depression, schizophrenia and psychotic symptoms. The underlying mechanisms are not well understood, although vitamin D is known to influence the immune system to promote a T helper (Th)-2 phenotype. At the same time, increased inflammation might be of importance in the pathophysiology of depression and suicide. We therefore hypothesized that suicidal patients would be deficient in vitamin D, which could be responsible for the inflammatory changes observed in these patients.

Original language	English
Pages (from-to)	210-219
Journal	Psychoneuroendocrinology
Volume	50
DOIs	https://doi.org/10.1016/j.psyneuen.2014.08.016
Publication status	Published - 2014

Subject classification (UKÄ)

Medicinal Chemistry
Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.psyneuen.2014.08.016

Elsevier__Grudet_et_al

http://www.ncbi.nlm.nih.gov/pubmed/25240206?dopt=Abstract

1 Article
1 Doctoral Thesis (compilation)
1 Licentiate Thesis

25(OH)D levels are decreased in patients with difficult-to-treat depression
Grudet, C., Lindqvist, D., Malm, J., Westrin, Å. & Ventorp, F., 2022 Feb 9, In: Comprehensive Psychoneuroendocrinology. 10, p. 1-7 100126.
Research output: Contribution to journal › Article › peer-review

Open Access
Vitamin D in Depression and Suicidality
Grudet, C., 2022, Lund: Lund University, Faculty of Medicine. 97 p.
Research output: Thesis › Doctoral Thesis (compilation)

Open Access
File
Vitamin D and inflammation in Major Depressive Disorder and suicidality
Grudet, C., 2019, Lund: Lund University: Faculty of Medicine. 56 p.
Research output: Thesis › Licentiate Thesis

Open Access
File

1 Active

Individanpassad behandling av patienter med depression, med särskilt fokus på suicidrisk.
Westrin, Å., Asp, M., Lindqvist, D., Westling, S., Fernström, J., Hallberg, L., Ambrus, L. & Reis, M.
2012/01/02 → …
Project: Research

Cite this

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title = "Suicidal patients are deficient in vitamin D, associated with a pro-inflammatory status in the blood.",

abstract = "Low levels of vitamin D may play a role in psychiatric disorders, as cross-sectional studies show an association between vitamin D deficiency and depression, schizophrenia and psychotic symptoms. The underlying mechanisms are not well understood, although vitamin D is known to influence the immune system to promote a T helper (Th)-2 phenotype. At the same time, increased inflammation might be of importance in the pathophysiology of depression and suicide. We therefore hypothesized that suicidal patients would be deficient in vitamin D, which could be responsible for the inflammatory changes observed in these patients.",

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AU - Grudet, Cécile

AU - Malm, Johan

AU - Westrin, Åsa

AU - Brundin, Lena

PY - 2014

Y1 - 2014

N2 - Low levels of vitamin D may play a role in psychiatric disorders, as cross-sectional studies show an association between vitamin D deficiency and depression, schizophrenia and psychotic symptoms. The underlying mechanisms are not well understood, although vitamin D is known to influence the immune system to promote a T helper (Th)-2 phenotype. At the same time, increased inflammation might be of importance in the pathophysiology of depression and suicide. We therefore hypothesized that suicidal patients would be deficient in vitamin D, which could be responsible for the inflammatory changes observed in these patients.

AB - Low levels of vitamin D may play a role in psychiatric disorders, as cross-sectional studies show an association between vitamin D deficiency and depression, schizophrenia and psychotic symptoms. The underlying mechanisms are not well understood, although vitamin D is known to influence the immune system to promote a T helper (Th)-2 phenotype. At the same time, increased inflammation might be of importance in the pathophysiology of depression and suicide. We therefore hypothesized that suicidal patients would be deficient in vitamin D, which could be responsible for the inflammatory changes observed in these patients.

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JF - Psychoneuroendocrinology

ER -

Suicidal patients are deficient in vitamin D, associated with a pro-inflammatory status in the blood.

Abstract

Subject classification (UKÄ)

UN SDGs

Access to Document

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Research output

25(OH)D levels are decreased in patients with difficult-to-treat depression

Vitamin D in Depression and Suicidality

Vitamin D and inflammation in Major Depressive Disorder and suicidality

Projects

Individanpassad behandling av patienter med depression, med särskilt fokus på suicidrisk.

Cite this