TY - JOUR
T1 - Suitability of haematopoietic cell donors
T2 - updated consensus recommendations from the WBMT standing committee on donor issues
AU - Worel, Nina
AU - Aljurf, Mahmoud
AU - Anthias, Chloe
AU - Buser, Andreas S.
AU - Cody, Meghann
AU - Fechter, Mirjam
AU - Galeano, Sebastian
AU - Greinix, Hildegard T.
AU - Kisch, Annika M.
AU - Koh, Mickey B.C.
AU - Mengling, Thilo
AU - Nicoloso, Grazia
AU - Niederwieser, Dietger
AU - Pulsipher, Michael A.
AU - Seber, Adriana
AU - Shaw, Bronwen E.
AU - Stefanski, Heather E.
AU - Switzer, Galen E.
AU - Szer, Jeff
AU - van Walraven, Suzanna M.
AU - Yang, Hung
AU - Halter, Jörg P.
PY - 2022/8
Y1 - 2022/8
N2 - The contribution of related donors to the globally rising number of allogeneic haematopoietic stem cell transplantations (HSCT) remains increasingly important, particularly because of the growing use of haploidentical HSCT. Compared with the strict recommendations on the suitability for unrelated donors, criteria for related donors allow for more discretion and vary between centres. In 2015, the donor outcome committee of the Worldwide Network for Blood and Marrow Transplantation (WBMT) proposed consensus recommendations of suitability criteria for paediatric and adult related donors. This Review provides updates and additions to these recommendations from a panel of experts with global representation, including the WBMT, the European Society for Blood and Marrow Transplantation donor outcome committee, the Center for International Blood and Marrow Transplant Research donor health and safety committee, the US National Marrow Donor Program, and the World Marrow Donor Association, after review of the current literature and guidelines. Sections on the suitability of related donors who would not qualify as unrelated donors have been updated. Sections on communicable diseases, clonal haematopoiesis of indeterminate potential, paediatric aspects including psychological issues, and reporting on serious adverse events have been added. The intention of this Review is to support decision making, with the goal of minimising the medical risk to the donor and protecting the recipient from transmissible diseases.
AB - The contribution of related donors to the globally rising number of allogeneic haematopoietic stem cell transplantations (HSCT) remains increasingly important, particularly because of the growing use of haploidentical HSCT. Compared with the strict recommendations on the suitability for unrelated donors, criteria for related donors allow for more discretion and vary between centres. In 2015, the donor outcome committee of the Worldwide Network for Blood and Marrow Transplantation (WBMT) proposed consensus recommendations of suitability criteria for paediatric and adult related donors. This Review provides updates and additions to these recommendations from a panel of experts with global representation, including the WBMT, the European Society for Blood and Marrow Transplantation donor outcome committee, the Center for International Blood and Marrow Transplant Research donor health and safety committee, the US National Marrow Donor Program, and the World Marrow Donor Association, after review of the current literature and guidelines. Sections on the suitability of related donors who would not qualify as unrelated donors have been updated. Sections on communicable diseases, clonal haematopoiesis of indeterminate potential, paediatric aspects including psychological issues, and reporting on serious adverse events have been added. The intention of this Review is to support decision making, with the goal of minimising the medical risk to the donor and protecting the recipient from transmissible diseases.
U2 - 10.1016/S2352-3026(22)00184-3
DO - 10.1016/S2352-3026(22)00184-3
M3 - Review article
C2 - 35901845
AN - SCOPUS:85134830083
SN - 2352-3026
VL - 9
SP - e605-e614
JO - The Lancet Haematology
JF - The Lancet Haematology
IS - 8
ER -
