SUMO4 M55V polymorphism affects susceptibility to type I diabetes in HLA DR3- and DR4-positive Swedish patients

S K Sedimbi; X R Luo; C B Sanjeevi; Ake Lernmark; Mona Landin-Olsson; Hans Arnqvist; Elizabeth Bjorck; Lennarth Nystrom; Lars Olof Ohlson; Bengt Schersten; Jan Ostman; M Aili; L E Baath; E Carlsson; H Edenwall; G Forsander

doi:10.1038/sj.gene.6364406

SUMO4 M55V polymorphism affects susceptibility to type I diabetes in HLA DR3- and DR4-positive Swedish patients

S K Sedimbi, X R Luo, C B Sanjeevi, Ake Lernmark, Mona Landin-Olsson, Hans Arnqvist, Elizabeth Bjorck, Lennarth Nystrom, Lars Olof Ohlson, Bengt Schersten, Jan Ostman, M Aili, L E Baath, E Carlsson, H Edenwall, G Forsander

Medicine/Emergency Medicine, Lund

Research output: Contribution to journal › Article › peer-review

Abstract

SUMO4 M55V, located in IDDM5, has been a focus for debate because of its association to type I diabetes (TIDM) in Asians but not in Caucasians. The current study aims to test the significance of M55V association to TIDM in a large cohort of Swedish Caucasians, and to test whether M55V is associated in those carrying human leukocyte antigen (HLA) class II molecules. A total of 673 TIDM patients and 535 age- and sex-matched healthy controls were included in the study. PCR-RFLP was performed to identify the genotype and allele variations. Our data suggest that SUMO4 M55V is not associated with susceptibility to TIDM by itself. When we stratified our patients and controls based on heterozygosity for HLA-DR3/DR4 and SUMO4 genotypes, we found that presence of SUMO4 GG increased further the relative risk conferred by HLA-DR3/DR4 to TIDM, whereas SUMO4 AA decreased the risk. From the current study, we conclude that SUMO4 M55V is associated with TIDM in association with high-risk HLA-DR3 and DR4, but not by itself.

Original language	English
Pages (from-to)	518-521
Journal	Genes and Immunity
Volume	8
Issue number	6
DOIs	https://doi.org/10.1038/sj.gene.6364406
Publication status	Published - 2007

Subject classification (UKÄ)

Clinical Medicine

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.gene.6364406

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Sedimbi, S. K., Luo, X. R., Sanjeevi, C. B., Lernmark, A., Landin-Olsson, M., Arnqvist, H., Bjorck, E., Nystrom, L., Ohlson, L. O., Schersten, B., Ostman, J., Aili, M., Baath, L. E., Carlsson, E., Edenwall, H., & Forsander, G. (2007). SUMO4 M55V polymorphism affects susceptibility to type I diabetes in HLA DR3- and DR4-positive Swedish patients. Genes and Immunity, 8(6), 518-521. https://doi.org/10.1038/sj.gene.6364406

@article{edc9938a859840f9b7ca1aad6b787cf7,

title = "SUMO4 M55V polymorphism affects susceptibility to type I diabetes in HLA DR3- and DR4-positive Swedish patients",

abstract = "SUMO4 M55V, located in IDDM5, has been a focus for debate because of its association to type I diabetes (TIDM) in Asians but not in Caucasians. The current study aims to test the significance of M55V association to TIDM in a large cohort of Swedish Caucasians, and to test whether M55V is associated in those carrying human leukocyte antigen (HLA) class II molecules. A total of 673 TIDM patients and 535 age- and sex-matched healthy controls were included in the study. PCR-RFLP was performed to identify the genotype and allele variations. Our data suggest that SUMO4 M55V is not associated with susceptibility to TIDM by itself. When we stratified our patients and controls based on heterozygosity for HLA-DR3/DR4 and SUMO4 genotypes, we found that presence of SUMO4 GG increased further the relative risk conferred by HLA-DR3/DR4 to TIDM, whereas SUMO4 AA decreased the risk. From the current study, we conclude that SUMO4 M55V is associated with TIDM in association with high-risk HLA-DR3 and DR4, but not by itself.",

author = "Sedimbi, {S K} and Luo, {X R} and Sanjeevi, {C B} and Ake Lernmark and Mona Landin-Olsson and Hans Arnqvist and Elizabeth Bjorck and Lennarth Nystrom and Ohlson, {Lars Olof} and Bengt Schersten and Jan Ostman and M Aili and Baath, {L E} and E Carlsson and H Edenwall and G Forsander",

year = "2007",

doi = "10.1038/sj.gene.6364406",

language = "English",

volume = "8",

pages = "518--521",

journal = "Genes and Immunity",

issn = "1476-5470",

publisher = "Nature Publishing Group",

number = "6",

}

Sedimbi, SK, Luo, XR, Sanjeevi, CB, Lernmark, A , Landin-Olsson, M, Arnqvist, H, Bjorck, E, Nystrom, L, Ohlson, LO, Schersten, B, Ostman, J, Aili, M, Baath, LE, Carlsson, E, Edenwall, H & Forsander, G 2007, 'SUMO4 M55V polymorphism affects susceptibility to type I diabetes in HLA DR3- and DR4-positive Swedish patients', Genes and Immunity, vol. 8, no. 6, pp. 518-521. https://doi.org/10.1038/sj.gene.6364406

TY - JOUR

T1 - SUMO4 M55V polymorphism affects susceptibility to type I diabetes in HLA DR3- and DR4-positive Swedish patients

AU - Sedimbi, S K

AU - Luo, X R

AU - Sanjeevi, C B

AU - Lernmark, Ake

AU - Landin-Olsson, Mona

AU - Arnqvist, Hans

AU - Bjorck, Elizabeth

AU - Nystrom, Lennarth

AU - Ohlson, Lars Olof

AU - Schersten, Bengt

AU - Ostman, Jan

AU - Aili, M

AU - Baath, L E

AU - Carlsson, E

AU - Edenwall, H

AU - Forsander, G

PY - 2007

Y1 - 2007

N2 - SUMO4 M55V, located in IDDM5, has been a focus for debate because of its association to type I diabetes (TIDM) in Asians but not in Caucasians. The current study aims to test the significance of M55V association to TIDM in a large cohort of Swedish Caucasians, and to test whether M55V is associated in those carrying human leukocyte antigen (HLA) class II molecules. A total of 673 TIDM patients and 535 age- and sex-matched healthy controls were included in the study. PCR-RFLP was performed to identify the genotype and allele variations. Our data suggest that SUMO4 M55V is not associated with susceptibility to TIDM by itself. When we stratified our patients and controls based on heterozygosity for HLA-DR3/DR4 and SUMO4 genotypes, we found that presence of SUMO4 GG increased further the relative risk conferred by HLA-DR3/DR4 to TIDM, whereas SUMO4 AA decreased the risk. From the current study, we conclude that SUMO4 M55V is associated with TIDM in association with high-risk HLA-DR3 and DR4, but not by itself.

AB - SUMO4 M55V, located in IDDM5, has been a focus for debate because of its association to type I diabetes (TIDM) in Asians but not in Caucasians. The current study aims to test the significance of M55V association to TIDM in a large cohort of Swedish Caucasians, and to test whether M55V is associated in those carrying human leukocyte antigen (HLA) class II molecules. A total of 673 TIDM patients and 535 age- and sex-matched healthy controls were included in the study. PCR-RFLP was performed to identify the genotype and allele variations. Our data suggest that SUMO4 M55V is not associated with susceptibility to TIDM by itself. When we stratified our patients and controls based on heterozygosity for HLA-DR3/DR4 and SUMO4 genotypes, we found that presence of SUMO4 GG increased further the relative risk conferred by HLA-DR3/DR4 to TIDM, whereas SUMO4 AA decreased the risk. From the current study, we conclude that SUMO4 M55V is associated with TIDM in association with high-risk HLA-DR3 and DR4, but not by itself.

U2 - 10.1038/sj.gene.6364406

DO - 10.1038/sj.gene.6364406

M3 - Article

C2 - 17554341

SN - 1476-5470

VL - 8

SP - 518

EP - 521

JO - Genes and Immunity

JF - Genes and Immunity

IS - 6

ER -

SUMO4 M55V polymorphism affects susceptibility to type I diabetes in HLA DR3- and DR4-positive Swedish patients

Abstract

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