Suppressed antibody and interleukin-6 responses to acute pyelonephritis in pregnancy

Christine Petersson, Spencer Hedges, Karin Stenqvist, Torsten Sandberg, Hugh Connell, Catharina Svanborg

Research output: Contribution to journalArticlepeer-review


This study examined the effect of pregnancy on the host response to acute pyelonephritis. Urine and serum samples were obtained at the time of diagnosis and after two weeks, from non-pregnant and pregnant women with acute pyelonephritis. The samples were analyzed for interleukin-6 (IL-6) and specific antibody activity to antigens extracted from the Escherichia coli strain infecting each patient. The host response to infection was further quantitated as fever, C-reactive protein, and renal concentrating capacity. Acute pyelonephritis in non-pregnant and pregnant women was accompanied by a significant serum and urine antibody response. The serum antibody response was significantly lower in the pregnant group. The IL-6 levels in serum and urine at diagnosis were significantly higher in the non-pregnant compared to the pregnant women. These results demonstrate that the immunosuppression of pregnancy includes the mucosal IL-6 and specific antibody responses to acute pyelonephritis caused by E. coli.

Original languageEnglish
Pages (from-to)571-577
JournalKidney International
Issue number2
Publication statusPublished - 1994 Feb

Subject classification (UKÄ)

  • Infectious Medicine


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