Survival of rats with N29 brain tumours after irradiation with 5 or 15 Gy and immunization with IFN-gamma secreting tumour cells

Bertil R Persson, Catrin Baureus Koch, Gustav Grafström, Crister Ceberg, Per Munck af Rosenschöld, Bengt Widegren, Leif Salford

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceedingpeer-review

Abstract

Intra cerebral tumours were inoculated into the brain of Fischer-344 syngeneic rats. After one week they were treated with either 5 or 15 Gy of Co-60-gamma radiation. The first immunization was given 1 hour before the radiation treatment and then two more times with 14-day intervals. Immunization was performed with 3 x 10(6) radiation sterilized IFN-gamma secreting tumour cells (N29) injected intraperitoneally. Neither radiation therapy with 5 or 15 Gy nor immunization with N29 cells alone had any significant effect on the length of survival of N29 tumour bearing rats. But radiation therapy with 5 Gy combined with immunization with IFN-gamma secreting syngeneic N29 cells resulted in 63 % complete remissions and significantly (p < 0.05) increased survival for the tumour bearing rats. Corresponding combination with 15 Gy RT resulted in 50% complete remissions. There is a possibility of a synergistic effect by optimal combination of radiation therapy and immunization.
Original languageEnglish
Title of host publicationBioMedical Engineering and Informatics
Subtitle of host publicationNew Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008
PublisherIEEE - Institute of Electrical and Electronics Engineers Inc.
Pages243-247
ISBN (Print)9780769531182
DOIs
Publication statusPublished - 2008
Event1st International Conference on Biomedical Engineering and Informatics - Sanya, China
Duration: 2008 May 272008 May 30

Publication series

NameBioMedical Engineering and Informatics: New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008
Volume2

Conference

Conference1st International Conference on Biomedical Engineering and Informatics
Country/TerritoryChina
CitySanya
Period2008/05/272008/05/30

Subject classification (UKÄ)

  • Neurology
  • Surgery
  • Radiology, Nuclear Medicine and Medical Imaging

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