@inproceedings{d7a364b944894668973e83e0ff2e97d8,
title = "Survival of rats with N29 brain tumours after irradiation with 5 or 15 Gy and immunization with IFN-gamma secreting tumour cells",
abstract = "Intra cerebral tumours were inoculated into the brain of Fischer-344 syngeneic rats. After one week they were treated with either 5 or 15 Gy of Co-60-gamma radiation. The first immunization was given 1 hour before the radiation treatment and then two more times with 14-day intervals. Immunization was performed with 3 x 10(6) radiation sterilized IFN-gamma secreting tumour cells (N29) injected intraperitoneally. Neither radiation therapy with 5 or 15 Gy nor immunization with N29 cells alone had any significant effect on the length of survival of N29 tumour bearing rats. But radiation therapy with 5 Gy combined with immunization with IFN-gamma secreting syngeneic N29 cells resulted in 63 % complete remissions and significantly (p < 0.05) increased survival for the tumour bearing rats. Corresponding combination with 15 Gy RT resulted in 50% complete remissions. There is a possibility of a synergistic effect by optimal combination of radiation therapy and immunization.",
author = "Persson, {Bertil R} and {Baureus Koch}, Catrin and Gustav Grafstr{\"o}m and Crister Ceberg and {Munck af Rosensch{\"o}ld}, Per and Bengt Widegren and Leif Salford",
year = "2008",
doi = "10.1109/BMEI.2008.345",
language = "English",
isbn = "9780769531182",
series = "BioMedical Engineering and Informatics: New Development and the Future - Proceedings of the 1st International Conference on BioMedical Engineering and Informatics, BMEI 2008",
publisher = "IEEE - Institute of Electrical and Electronics Engineers Inc.",
pages = "243--247",
booktitle = "BioMedical Engineering and Informatics",
address = "United States",
note = "1st International Conference on Biomedical Engineering and Informatics ; Conference date: 27-05-2008 Through 30-05-2008",
}