Sympathetic skin vasoconstriction--further evaluation using laser Doppler techniques

F Holmlund, Carolin Freccero, S Bornmyr, J Castenfors, A-M Johansson, J Nordquist, Göran Sundkvist, H Svensson, Per Wollmer

Research output: Contribution to journalArticlepeer-review


The aim of this study was to quantify the reflex sympathetic vasoconstriction in skin at different depths. Twenty healthy subjects were studied. Finger skin blood flow was measured using laser Doppler perfusion imaging (LDPI) and laser Doppler perfusion monitoring (LDPM). In LDPM, a probe with fibres separated 0.25 mm (deep) and 0.14 mm (superficial) from the illuminating fibre was used. Local heating (40 degrees C) was achieved with a Peltier element, and reflex vasoconstriction induced by immersion of the contra-lateral hand and forearm for 3 min in water at 15 degrees C. The change in skin blood flow was measured and a vasoconstriction index (VAC: cooling/before cooling) calculated. VAC indices of LDPI, LDPM-0.25 and LDPM-0.14 were 0.60, 0.59 and 0.60, respectively. The two components of the LDPM perfusion value, blood cell velocity and concentration, were studied separately. Their contributions in LDPM-0.25 were roughly the same, whereas the velocity component dominated in LDPM-0.14, although their relative responses in the two channels were similar. We conclude that sympathetic skin vasoconstriction does not significantly differ in two compartments, as probed with fibres separated by 0.25 and 0.14 mm. Blood cell velocity is influenced in a proportional way, as is concentration.
Original languageEnglish
Pages (from-to)287-291
JournalClinical Physiology
Issue number3
Publication statusPublished - 2001

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Reconstructive Surgery (013240300), Diabetes Epidemiology and Neuropathy (013241560), Clinical Physiology and Nuclear Medicine Unit (013242320)

Subject classification (UKÄ)

  • Radiology, Nuclear Medicine and Medical Imaging
  • Surgery
  • Endocrinology and Diabetes


  • concentration
  • contra-lateral cooling
  • fibre separation
  • finger skin blood flow
  • laser Doppler perfusion imaging
  • laser Doppler perfusion monitoring
  • local heating
  • measuring depth
  • sympathetic vasoconstriction
  • velocity


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