Abstract
Syndecans are transmembrane proteoglycans with heparan and chondroitin sulfate chains attached to their extracellular domain. Like many proteoglycans, they interact with a large number of ligands, such as growth factors, adhesion receptors, soluble small molecules, proteinases, and other extracellular matrix proteins to initiate downstream signaling pathways. Syndecans play a major role in inflammation, mainly by regulating leukocyte extravasation and cytokine function. At the same time, syndecans can undergo cytokine mediated changes in their expression levels during inflammation. The function of syndecans during inflammation appears to depend on the stage of inflammation, sulfation of heparan/chondroitin sulfate chains, the rate of ectodomain shedding and the solubility of the ectodomains. From the current literature, it is clear that syndecans are not only involved in the initial recruitment of pro-inflammatory molecules but also in establishing a balanced progression of inflammation. This review will summarize how cell surface and soluble syndecans regulate multiple aspects of inflammation.
Original language | English |
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Article number | 227 |
Journal | Frontiers in Immunology |
Volume | 11 |
DOIs | |
Publication status | Published - 2020 |
Externally published | Yes |
Bibliographical note
Copyright © 2020 Gopal.Subject classification (UKÄ)
- Biochemistry and Molecular Biology
- Cell and Molecular Biology
Free keywords
- Animals
- Cytokines/physiology
- Extracellular Matrix/physiology
- Humans
- Inflammation/etiology
- Leukocytes/physiology
- Signal Transduction/physiology
- Syndecans/physiology