Synthesis of 2'-Deoxyuridine 5'-(α,β-Imido)triphosphate: A Substrate Analogue and Potent Inhibitor of dUTPase

Chemistry

• Synthesis (Chemical) 100%
• Inhibitor 100%
• Procedure 50%
• Donor 50%
• Phosphate 50%
• Dioxygen 50%
• % Inhibition 50%
• Hydrolysis 50%
• Pharmacological Metabolism 50%
• Phosphorylation 50%

Biochemistry, Genetics and Molecular Biology

• Enzyme 100%
• Synthesis 100%
• Substrate Analog 100%
• Enzymatic Hydrolysis 33%
• Phosphate 33%
• Escherichia coli 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Deoxyuridine Triphosphate Pyrophosphatase 100%
• Thymidine 40%
• Competitive Inhibitor 20%
• Phosphate 20%