Synthetic modification of salinomycin: selective O-acylation and biological evaluation

Björn Borgström; Xiaoli Huang; Martin Posta; Cecilia Hegardt; Stina Oredsson; Daniel Strand

doi:10.1039/c3cc45983g

Synthetic modification of salinomycin: selective O-acylation and biological evaluation

Björn Borgström, Xiaoli Huang, Martin Posta, Cecilia Hegardt, Stina Oredsson, Daniel Strand

Research output: Contribution to journal › Article › peer-review

Abstract

Salinomycin has found renewed interest as an agent for prevention of cancer recurrence through selectively targeting cancer stem cells. Strategies for generation of improved salinomycin analogs by individual modification of its hydroxyl groups are presented. An evaluation of the dose-response effects of the resulting library on breast cancer cell lines shows that acylation of the C20 hydroxyl can be used to improve IC50 values down to one fifth that of salinomycin.

Original language	English
Pages (from-to)	9944-9946
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	85
DOIs	https://doi.org/10.1039/c3cc45983g
Publication status	Published - 2013

Subject classification (UKÄ)

Chemical Sciences

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c3cc45983gLicence: CC BY

1 Doctoral Thesis (compilation)

Salinomycin analogs: Mechanistic probes and structure–activity relationships against cancer stem cells
Borgström, B., 2016 Sept, Lund: Lund University, Faculty of Science, Department of Chemistry, Centre for Analysis and Synthesis. 69 p.
Research output: Thesis › Doctoral Thesis (compilation)

Cite this

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title = "Synthetic modification of salinomycin: selective O-acylation and biological evaluation",

abstract = "Salinomycin has found renewed interest as an agent for prevention of cancer recurrence through selectively targeting cancer stem cells. Strategies for generation of improved salinomycin analogs by individual modification of its hydroxyl groups are presented. An evaluation of the dose-response effects of the resulting library on breast cancer cell lines shows that acylation of the C20 hydroxyl can be used to improve IC50 values down to one fifth that of salinomycin.",

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AU - Borgström, Björn

AU - Huang, Xiaoli

AU - Posta, Martin

AU - Hegardt, Cecilia

AU - Oredsson, Stina

AU - Strand, Daniel

PY - 2013

Y1 - 2013

N2 - Salinomycin has found renewed interest as an agent for prevention of cancer recurrence through selectively targeting cancer stem cells. Strategies for generation of improved salinomycin analogs by individual modification of its hydroxyl groups are presented. An evaluation of the dose-response effects of the resulting library on breast cancer cell lines shows that acylation of the C20 hydroxyl can be used to improve IC50 values down to one fifth that of salinomycin.

AB - Salinomycin has found renewed interest as an agent for prevention of cancer recurrence through selectively targeting cancer stem cells. Strategies for generation of improved salinomycin analogs by individual modification of its hydroxyl groups are presented. An evaluation of the dose-response effects of the resulting library on breast cancer cell lines shows that acylation of the C20 hydroxyl can be used to improve IC50 values down to one fifth that of salinomycin.

U2 - 10.1039/c3cc45983g

DO - 10.1039/c3cc45983g

M3 - Article

C2 - 24037337

SN - 1364-548X

VL - 49

SP - 9944

EP - 9946

JO - Chemical Communications

JF - Chemical Communications

IS - 85

ER -

Synthetic modification of salinomycin: selective O-acylation and biological evaluation

Abstract

Subject classification (UKÄ)

UN SDGs

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Research output

Salinomycin analogs: Mechanistic probes and structure–activity relationships against cancer stem cells

Cite this