Synthetic modification of salinomycin: selective O-acylation and biological evaluation

Björn Borgström, Xiaoli Huang, Martin Posta, Cecilia Hegardt, Stina Oredsson, Daniel Strand

Research output: Contribution to journalArticlepeer-review


Salinomycin has found renewed interest as an agent for prevention of cancer recurrence through selectively targeting cancer stem cells. Strategies for generation of improved salinomycin analogs by individual modification of its hydroxyl groups are presented. An evaluation of the dose-response effects of the resulting library on breast cancer cell lines shows that acylation of the C20 hydroxyl can be used to improve IC50 values down to one fifth that of salinomycin.
Original languageEnglish
Pages (from-to)9944-9946
Number of pages3
JournalChemical Communications
Issue number85
Publication statusPublished - 2013

Subject classification (UKÄ)

  • Chemical Sciences


Dive into the research topics of 'Synthetic modification of salinomycin: selective O-acylation and biological evaluation'. Together they form a unique fingerprint.

Cite this