Synthetic polymers as solubilizing vehicles for enzymes in water-poor media

Patrick Adlercreutz; Bo Matiasson; Marina Otamiri

doi:10.1016/0968-0896(94)80023-5

Synthetic polymers as solubilizing vehicles for enzymes in water-poor media

Patrick Adlercreutz, Bo Matiasson, Marina Otamiri

Biotechnology

Lund University

Research output: Contribution to journal › Review article › peer-review

Abstract

A recent method for exposing enzymes to organic solvents is reviewed. By complex formation between the enzyme and polymers that per se are soluble in organic solvents it is possible to disperse the enzyme in the organic medium in such a way that an optically transparent (in the visible region) solution is obtained. After reaction, the separation of the enzyme from the organic medium can be obtained simply by addition of water. The enzyme can be recovered from the water phase. Physicochemical studies have revealed that the enzyme is more stable in the complex-bound form.

Original language	English
Pages (from-to)	529-533
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry
Volume	2
Issue number	6
DOIs	https://doi.org/10.1016/0968-0896(94)80023-5
Publication status	Published - 1994 Jan 1

Subject classification (UKÄ)

Biocatalysis and Enzyme Technology

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10.1016/0968-0896(94)80023-5

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abstract = "A recent method for exposing enzymes to organic solvents is reviewed. By complex formation between the enzyme and polymers that per se are soluble in organic solvents it is possible to disperse the enzyme in the organic medium in such a way that an optically transparent (in the visible region) solution is obtained. After reaction, the separation of the enzyme from the organic medium can be obtained simply by addition of water. The enzyme can be recovered from the water phase. Physicochemical studies have revealed that the enzyme is more stable in the complex-bound form.",

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N2 - A recent method for exposing enzymes to organic solvents is reviewed. By complex formation between the enzyme and polymers that per se are soluble in organic solvents it is possible to disperse the enzyme in the organic medium in such a way that an optically transparent (in the visible region) solution is obtained. After reaction, the separation of the enzyme from the organic medium can be obtained simply by addition of water. The enzyme can be recovered from the water phase. Physicochemical studies have revealed that the enzyme is more stable in the complex-bound form.

AB - A recent method for exposing enzymes to organic solvents is reviewed. By complex formation between the enzyme and polymers that per se are soluble in organic solvents it is possible to disperse the enzyme in the organic medium in such a way that an optically transparent (in the visible region) solution is obtained. After reaction, the separation of the enzyme from the organic medium can be obtained simply by addition of water. The enzyme can be recovered from the water phase. Physicochemical studies have revealed that the enzyme is more stable in the complex-bound form.

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JO - Bioorganic and Medicinal Chemistry

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ER -

Synthetic polymers as solubilizing vehicles for enzymes in water-poor media

Abstract

Subject classification (UKÄ)

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