T cell receptor (TCR) signaling in health and disease

Kinjal Shah, Amr Al-Haidari, Jianmin Sun, Julhash U. Kazi

Research output: Contribution to journalReview articlepeer-review


Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in changes at the molecular and cellular levels in T cells. The outside environmental cues are translated into various signal transduction pathways within the cell, which mediate the activation of various genes with the help of specific transcription factors. These signaling networks propagate with the help of various effector enzymes, such as kinases, phosphatases, and phospholipases. Integration of these disparate signal transduction pathways is done with the help of adaptor proteins that are non-enzymatic in function and that serve as a scaffold for various protein–protein interactions. This process aids in connecting the proximal to distal signaling pathways, thereby contributing to the full activation of T cells. This review provides a comprehensive snapshot of the various molecules involved in regulating T cell receptor signaling, covering both enzymes and adaptors, and will discuss their role in human disease.
Original languageEnglish
Article number412
JournalSignal Transduction and Targeted Therapy
Issue number1
Publication statusPublished - 2021

Subject classification (UKÄ)

  • Cell and Molecular Biology


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